富硒蛹虫草对小鼠降血脂和抗氧化作用的影响_医学论文.docVIP

富硒蛹虫草对小鼠降血脂和抗氧化作用的影响_医学论文 富硒蛹虫草对小鼠降血脂和抗氧化作用的影响_医学论文 作者：钟鸣，高丹，胡昆，陈丽静，张丽，李浩戈，张月 【摘要】 目的探讨富硒蛹虫草的降血脂和抗氧化作用。方法昆明种雄性小鼠60只，随机分4组(n=15只/组)：正常对照组、高脂模型组、普通蛹虫草组、富硒蛹虫草组。用不同的饲料持续喂养5周，每周的固定时间称量小鼠体质量1次，第5周断头取血后解剖小鼠，检测血清总胆固醇(T-CHO)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及肝组织谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）和丙二醛（MDA）含量。结果富硒蛹虫草组与高脂模型组相比，T-CHO和TG的含量降低，HDL-C的含量升高，均达到了显著水平(0.05) LDL-C含量降低(Pgt0.05)；GSH-Px和SOD活性升高，MDA含量降低，均达到了显著水平(0.05)。并且富硒蛹虫草的降血脂与抗氧化作用均高于普通蛹虫草。结论富硒蛹虫草具有良好的降血脂和抗氧化作用。 【关键词】 蛹虫草； 硒； 降血脂； 抗氧化 The Effect of Selenium-enrich Cordyceps militaris on Hypolipidemic and Qnti-oxidant on Mice 　　Abstract：ObjectiveTo discuss the hypolipidemic and anti-oxidant effect of Se-enrich C.militaris. MethodsSixty kunming male mice were randomly assigned to four groups (n=15 in each group): base control group, high lipid model group, ordinary C.militaris group, Se-enrich C.militaris group. With different feed continuous feeding for five weeks, the body weights of mice were weighed at fixed-time weekly. In the fifth week, the mice were decapitated after taking out the blood from mice. The total cholesterol(T-CHO), triglyeride(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C) of serum and the glutathione peroxidase(GSH-Px), superoxide dismutase(SOD), malondialdehyde(MDA) of liver tissue were measured. ResultsCompared Se-enrich C.militaris group to high lipid model group, T-CHO and TG content decreased, HDL-C content increased to significant levels (0.05) LDL-C content decreased(Pgt0.05). GSH-Px and SOD activity increased, MDA content decreased to a significant level (0.05). And Se-enrich C.militaris of hypolipidemic and anti-oxidant were higher than ordinary C.militaris. ConclusionSe-enrich C.militaris has good hypolipidemic and anti-oxidant effect. 　　Key words：Cordyceps militaris (Fr.) Link Selenium Hypolipidemic Anti-oxidant 硒是目前已知的14种人体必需的微量元素之一，被科学家誉为“生命的火种”“抗癌之王”［1］。研究表明，人类心血管疾病、艾滋病、肿瘤、高血压病、糖尿病、肺部疾病等均与硒缺乏有关［2～6］。蛹虫草作为食药两用真菌，以其降压、降脂、抗疲劳、抗衰老等作用而备受人们的