感染后肠易激综合征与溃疡性结肠炎缓解期病人直肠黏膜细胞因子的表达_医学论文.docVIP

感染后肠易激综合征与溃疡性结肠炎缓解期病人直肠黏膜细胞因子的表达_医学论文 感染后肠易激综合征与溃疡性结肠炎缓解期病人直肠黏膜细胞因子的表达_医学论文 作者：鞠辉 王光兰 张海燕 赵清喜 魏良洲 刘希双 【摘要】 目的 探讨感染后肠易激综合征（PI）与溃疡性结肠炎（UC）缓解期病人肠黏膜细胞因子的表达，从神经免疫机制分析肠易激综合征（IBS）与炎症性肠病（IBD）的相关性。方法 PI组病人20例，UC组病人45例，正常对照组30例，结肠镜下取直肠黏膜标本，采用免疫组化方法检测其肠黏膜细胞因子的表达情况。结果PI病人直肠IFN、IL阳性表达高于对照组（χ2=14.012、13.931,0.01），而与UC病人比较差异无统计学意义（χ2=2.290、2.323,Pgt0.05）。PI病人直肠黏膜P物质（SP）强度均值高于对照组（t=3.722,0.01），而与UC病人比较差异无统计学意义（t=1.643,Pgt0.05）。直肠黏膜IFN、IL阳性表达的PI病人SP强度均值高于对照组（t=2.301、2.252,0.05），与UC病人比较差异无统计学意义(t=1.574,1.676,Pgt0.05)。结论 PI与IBD之间可能存在某种相关性。 【关键词】 肠易激综合征；结肠炎,溃疡性；P物质；细胞因子类 　The incidence of functional disorder of intestine isabout 22%～25% after the bowel is acutely infected. Symptoms like IBS occur in some patients when the pathogens, such as enteric virus, bacterium or parasite, have been eliminated and the mucosal inflammation vanished, which is called postinfective irritable bowel syndrome (PIIBS)[1]. In remission, clinical manifestations of UC often resemble irritable bowel like syndrome (IBLS), which is characterized by abdominal pain and diarrhea without gastrointestinal tract and biochemical abnormality. The therapeutic efficacy is not satisfactory with aminosalicylic acid alone[2]. A followup study of the patients with initial diagnosis of IBS indicated that they were at obviously high risk of developing IBD, with a relative risk being 16.3, which suggestive of certain correlation really exists between IBS and IBD[3]. The purpose of this study was to investigate the expressions of SP, IFNγ and IL2 in rectal mucosa of patients with PIIBS and UC in remission, analyze the association between IBS and IBD based on neuroimmunomechanism. 　　1 MATERIALS AND METHODS 　　1.1 Case selection 　　According to Rome criteria Ⅱ[4], 45 diarrhea mean age was 39.17±10.89 years, were randomly recruited from outpatient clinic of gastroenterology at The Affiliated Hospital of Qingdao University Medical College. Of whom, 20 were classified as PIIBS meeting the RomeⅡcriteria, with a history