CpG寡聚核苷酸的结构和种属特异性.pdfVIP

CpG ODN CpG ,11* 116034 116036 CpG CpG CpG CpG CpG CpG (PAMP)(PRR) CpG() [1] 20 DNA DNA (PAMP) “”1995 Krieg [1] DNA DNA CpG ( CpG CpG ) DNA DNA [2-4] Tokunaga DNA AACGTT, AGCGCT, ATCGAT, CGATCG, CGTACG, CGCGCG, GCGCGC, TCGCGA 69.8%- [5] 1995 Krieg DNA B 150 CpG (5‘—CG 3’)B [1] CpG CpG CpG CpG (CpG ) CpG (CpG ODN) CpG ODN 1 CpG ODN CpG ODN CpG ODN [6] Klinman 2002 ODN CpG ODN K ODN D ODN K ODN IgM IL-10 IL-6 D ODN D ODN K D ODN --CG- -3-4 CpG 11 *1983— DNACpG ODN Tel Email:ammenwang@ 93 D ODN 3’ 4-6 poly-G 18 K ODN CpG CpG 5’ 3’TpT ApT 12 K ODN CpG ODN CpG ODNCpG 5’ODN K ODN ODN DNA [7] Hartmann CpG ODN DC IFN-α CpG-AIFN-αB CpG-B[8] CpG-A CG 3’5’poly-G CpG-B 5’TCGTCG GTCGTT CpG-A CpG-B ODN CpG-C CpG CpG-A CG 5’ CpG-B TCGTCG GTCGTT CpG-C B DC IFN-αVollmer CpG-B B NK CpG-A NK IFN-α CpG-C [9] Rothenfusser CpG-A CpG-B CpG-A DC + + CD8 T CpG-B CD8 T CpG-A CpG-B CD8+ T CpG-A CD8+ [10] T CpG-A CpG-B CD8+ T CD8+ T CpG ODN KCpGCpG-BDCpGCpG-A KlinmanCpG ODNKDCODN(1)CpG ODN CpG ODN [11] KCpGIL-6 IgM IFN CpGODN CpGODN CpGODNCpGODN1/45’ CpGODN5’CpG ODN3’