DNA1- (Last week).pptVIP

DNA1: (Last week) DNA2: Aligning ancient diversity DNA2: diversity continuity Applications of Dynamic Programming Alignments Scores Increasingly complex (accurate) searches Hardness of (multi-) sequence alignment A Multiple Alignment of Immunoglobulins Scoring matrix based on large set of distantly related blocks: Blosum62 Scoring Functions and Alignments Scoring function: ?(match) = +1; ?(mismatch) = -1; ?(indel) = -2; ?(other) = 0. Alignment score: sum of columns. Optimal alignment: maximum score. Calculating Alignment Scores DNA2: Aligning ancient diversity What is dynamic p