别嘌呤醇用药调查及其药疹患者HLA-B-5801基因型分析.pdfVIP

w、^w·zgys·org 研究论文 别嘌呤醇用药调查及其药疹患者HLA．B半5801基因型分析 张亚同1 时正媛2 胡欣1 孙春华1 李可欣1 杨莉萍1 (1．卫生部北京医院药学部北京100730；2．沈阳药科 大学) 摘要目的：调查别嘌呤醇用药情况并分析可能引起别嘌呤醇皮疹的HLA．B+5801基因型。方法：收集我院应用别嘌呤 醇患者的人口流行病学特征，分析发生皮疹患者的HLA-B+5801基因型。结果：监测服用别嘌呤醇患者421名，别嘌呤醇平 均剂量145．8 mg·d～。4例患者分别出现单纯斑丘疹、结节性药疹、慢性荨麻疹和大疱型类天疱疮等药疹，其中仅1例患者检 皮疹的相关性有待进一步确证。 关键词别嘌呤醇；基因型；HLA-B’5801；药疹 中图分类号：R968文献标识码：A 文章编号：1008-049X(2011)07-0952-03 of MedicationandHLA-B+5801ofPatientswith AnalysisAllopurinol Genotype DrugEruption Zhang Xinl，SunChunhual，Li ofClinical Yatong‘，ShiZhengyuan2，Hu Kexinl，YangLipin91(1Department Pharmaceutical Hospital，Beijing100730，China；2Shenyang University) ABSTRACT the medicationandHI．A—B+5801 ofthe with after Objective：Toanalyzeallopurinol eruption genotypepatientsdrug usedto administration．Method：Awas characteristicsofthe administered prospectiveanalysis studyepidemiologieal patients allopuri- nolinour with caused monitored．Theblood hospital．弧e severeones，were patientsdrugeruptionpossibly byallopurinol，especially werecollectedto HLA‘B5801 were421 administrated samples analyze genotype．Result：Therepatients allopurinolaltogether．The mean of dose Wag145．8 foureaseswere as caused and allopurinol mg-d～．Only diagnoseddrugeruptionbyallopurinolamongthem， one showedHLA．B+5801 thePCR．SSP with or inourhos． only patients positiveby test．Conclusion：The’patientshyperuricemiagout were elder