当归芍药散抗衰老作用的松果体机制.pdfVIP

当归芍药散抗衰老作用的松果体机制 田荣波。何宏文2 摘要 目的探讨当归芍药散是否通过改善松果体的功能而发挥抗衰老作用。方法老年SD大鼠40 只，分别分为假手术组、去松果体组、假手术给药组、去松果体给药组，以去松果体术造成衰老模型，灌胃当归 芍药散水煎剂3周，然后用Morris水迷宫测试其学习记忆能力，用放射免疫法测血清褪黑激素(MLT)浓度。 结果去松果体组平均逃避潜伏期明显高于其余各组(P0．05)；假手术给药组穿环次数、T象限游泳距离 较，假手术给药组白天MLT浓度增高(P0．05)。结论当归芍药散可以促进MLT的分泌，改善学习记忆 能力。去除松果体后该方药的作用减弱，当归芍药散促进松果体功能是其抗衰老作用的机制之一。 关键词 当归芍药散；松果体；褪黑激素；衰老 PinealMechanismof Powderon TIAN andHE MedicalCol— DangguiShaoyao Anti-agingRong-bo Hong—wen Juhou legeof University，Hunal(416000) Abstract To whether of func- Objective ShaoyaoPowder(DSP)is study Danggui bywayimprovingpineal tiontorealizeits effects．Methodsratswere dividedintothesham anti—aging Fortyaged randomly operatedgroup shammedicated andmedicated (A)，thepinealectomizedgroup(B)，the group(C)，thepinealectomized group medicationwas ofDSPfor and 3 ofratswasob— (D)．The givengastricperfusion weeks．Learningmemoryability served Morriswatermaze andtheserum oftheratswasmeasuredradio- using melatonin(MLT)concentration by The in Bwas thanthatinother immunoassay．ResultsaverageescapelatencyGroup significantlylonger groups timesof the andthe of distancein Cwere (P0．05)．The passingthroughplatform percentageswimming Group thanthoseinother serumMLTwas at thanat in significantlyhigher groups(P0．05)．Thehigher night