肿瘤坏死因子抑制剂的研究进展.pdfVIP

现代药物与临床 Drugs Clinic 第 27 卷 第 2 期 2012 年 3 月 • 143 • 肿瘤坏死因子抑制剂的研究进展 1 1 2 3* 钱 钰 ，周建平 ，高 鹏 ，徐 晨 1. 中国药科大学 药学院，江苏 南京 211198 2. 广东药学院，广东 广州 510006 3. 北京三元基因工程有限公司，北京 102600 摘 要：类风湿性关节炎（rheumatoid arthritis ，RA ）、节段性肠炎（Crohn′s disease，CD ）等疾病具有类似的发病机制。肿 瘤坏死因子（tumor necrosis factor ，TNF ）在这些疾病的发生发展中具有非常重要的作用。TNF 分子在细胞因子免疫调节网 络中位于中枢环节，是重要的炎症介质，过量的 TNF 导致炎症的发生。目前上市的 TNF 抑制剂种类繁多，治疗效果显著。 然而随着 TNF 抑制剂广泛应用，这类药物的安全性逐渐受到重视。本文综述了 TNF 与疾病关系、上市的 TNF 蛋白抑制剂 分子结构、临床应用等方面，重点关注药物潜在的不良反应，并对近期新型 TNF 抑制剂的研究开发进行总结。 关键词：肿瘤坏死因子；抑制剂；类风湿性关节炎；不良反应 中图分类号：R979.5 文献标志码：A 文章编号：1674 - 5515(2012)02 - 0143 - 07 Research progress on tumor necrosis factor inhibitors 1 1 2 3 QIAN Yu , ZHOU Jian-ping , GAO Peng , XU Chen 1. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China 2. Guangdong Pharmaceutical University, Guangzhou 510006, China 3. Beijing Tri-Prime Genetic Engineering Co., Ltd., Beijing 102600, China Abstract ： The pathogenesis mechanisms of diseases like rheumatoid arthritis (RA), Crohn’s disease (CD) are quite similar. Tumor necrosis factor (TNF) is likely to be of fundamental importance on the generation and development and plays a key role on the cytokine immune network. High level of TNF could induce inflammation. There are some TNF inhibitors marketed or in research, and both of them had remarkable efficacy. Along with TNF inhibitors being widely used, it’s more important to concern about the safety profiles. Therefore, this article reviews the relationship between TNF and diseases, and five TNF protein inhibitors available through structures and clinical use, keeping eyes on their possible side effect and providing some new TNF inhibitors with bright future. Key words ：tumor necrosis factor (TNF); inhibitors; rheumatoid arthritis (RA); side effect 肿瘤坏死因子（tumor