聚类分析法在鼻腔鼻窦恶性肿瘤微血管.pdfVIP

2010;30(10) 南方医科大学学报(JSouthMedUniv) 窑2357窑 聚类分析法在鼻腔鼻窦恶性肿瘤微血管检测中的应用 1 2 1 3 3 1 3 贾海英 袁莫天石 袁张涛 袁山艳春 袁王继群 渊暨南大学 第一医院耳鼻咽喉头颈外科袁 医学院耳鼻喉教研室袁 2 广东广州 510632曰 仁伯爵医院耳鼻咽喉科袁中国澳门冤 摘要院目的探讨聚类分析法在鼻腔鼻窦恶性肿瘤渊NPMT冤微血管检测中的应用价值遥 方法分别用微血管计数和聚类 分析结果统计鼻腔鼻窦恶性肿瘤与微血管密度渊MVD冤的相关性袁比较其结果是否一致遥 结果聚类分析法可将MVD 计数聚为2类袁经检验得出MVD 与鼻腔鼻窦恶性肿瘤尧癌旁和对照组的表达存在统计学差异渊P0.01冤袁这与微血管计 数方差分析结果一致遥 结论认为聚类分析法可以用于MVD计数结果聚类袁用于鼻腔鼻窦肿瘤与MVD 的研究袁简化 了MVD计数步骤袁为肿瘤微血管的研究提供重要的方法遥 关键词院聚类分析曰鼻肿瘤曰微血管曰微血管密度 中图分类号院R739.62 文献标志码院A 文章编号院1673-4254(2010)10-2357-03 Clusteranalysisinmicrangiumdetectioninmalignantnasalandparanasalsinustumor 1 2 1 3 3 JIAHai-ying ,MOTian-shi,ZHANGTao,SHANYan-chun,WANGJi-qun 1DepartmentofOtorhinolaryngologyandHeadandNeckSurgery, FirstAffiliatedHospitalofJinanUniversity, Guangzhou510630, China; 2Department of Otorhinolaryngology, Centro Hospitalar Conde De S. Januario, Macau, China; 3Department of Otorhinolaryngology,MedicalCollegeofJinanUniversity,Guangzhou510630,China Abstract: Objective Tostudytheapplicationofclusteranalysisinmicrangiumdetectioninmalignantnasalandparanasal sinustumor. Methods Microvesseldensity (MVD) countingandclusteranalysiswereusedtodetectthemicrangiumin patientswithmalignantnasalandparanasalsinustumortoassesstheassociationbetweenthemalignancyandMVD. Results Accordingtoclusteranalysis, theMVDcountingcouldbeclusteredintotwogroups, and theMVDshowed significant differencesbetweenthetumortissues,adjacentnormaltissueandthecontrolgroup(P0.01),aresultconsistentwiththatby analysisofvarianceoftheMVD. ConclusionClusteranalysiscanbeusedinclusteringofMVDcountinginmalignantnasal andparanasalsinustumortosimplifyMVDcounting, andoffersanimportantanalyticmethodformicrangiumanalysisin tumors. Key