NK细胞的新免疫功能_免疫记忆性.pdfVIP

NK : 10 8 NK : ( 中国科学技术大学免疫学研究所, 合肥23002 ) R392 A 1000484X(2009) [ ] ( NK ) memoryNK NK , memory T + memoryNK , ( MCMV) , Ly49H memoryNK Ly49H KLRG1CD43Ly6C, CD2 ( DNFB ) ,memoryNK , + + + Thy1 Ly49CI NK , NK 10% Ly49H memoryNK NK1. 1 + Ly49H , IFNNK , NK1. 1Ly49H memoryNK CD10 a DNFB TB Rag2- / - NK T NK , NK [ ] NK ; ; ; A new function of NK cells: adaptive o memo y? ZHENGMeiJuan, TIAN ZhiGang. Institute of Immunology, University fo Science Technology of China,Hfe ei 23002 , China [Abst act] Recent reports have indicated that NK cells may have the function of immunological memory in common with cells of the adaptive immune system.Memory NK cells move through the four phases of the adaptive immune response proliferation, contraction, mem ory and recall which was similar to the Tcell responses.Memory NK cells have special phenotypes. During MCMV infection,memory NK cells showed a greater expression of Ly49H, KLRG1, CD43 and Ly6C, and a decreased expression of CD2 . In hapten ( DNFB)induced contact + + hypersensitivity model, the sorted liver NK cell subsets with the phenotype of Thy1 Ly49CI had the transferable memory activity, occupying + around 10% of hepaedtic NK cells.These Ly49H memory NK cells might produce more IFNgamma ex vivo in response to platebound anti + body against NK1. 1 or Ly49H. Degranulation by Ly49H memory NK cells was also enhanced, as assessed by CD10 a expression after ex vivo stimulation with anti NK1. 1.Memory NK cells may move through the same migratory