加味寿胎丸对免疫性反复性早期流产患者抗子宫内膜抗体的影响.pdfVIP

-10- Clinical Journal of Chinese Medicine 2014 Vol.(6) No.32 加味寿胎丸对免疫性反复性早期流产患者抗子宫 内膜抗体的影响 Effects of Shoutai Wan on EmAb in patients with ERSA 逯克娜 陈慧侬 （广西中医药大学第一附属医院，广西 南宁，530023 ） 中图分类号：R714.21 文献标识码：A 文章编号：1674-7860 （2014 ）32-0010-02 证型：AGD 【摘 要】 目的：观察加味寿胎丸对免疫性反复性早期流产（ERSA ）患者血清抗子宫内膜抗体（EmAb ）转阴率的影响。 方法：将60 例EmAb 阳性的ERSA 患者随机分为两组，中药治疗组30 例，采用加味寿胎丸治疗，连续用药3 个月，确定宫内妊 娠后服法同前，连续用药至妊娠 12 周停药；西药对照组30 例，非孕期给予阿司匹林及泼尼松治疗，连续用药3 个月，确定宫内 妊娠后给予人绒毛膜促性腺激素与黄体酮治疗，连续用药至妊娠 12 周停药。观察治疗前后患者血清 EmAb 的转阴率。结果：治 疗后治疗组EmAb 转阴率是83.3%，优于对照组60.0% （P0.05 ）。结论：加味寿胎丸对免疫性ERSA 患者EmAb 消除有显著临床 疗效，有利于改善妊娠结局。 【关键词】免疫性；反复自然流产；中医药疗法 【Abstract 】 Objective: To observe clinical effects of Shoutai Wan on EmAb negative rate in patients with ERSA. Methods: 10 patients with EmAb positive were randomly divided into two groups, 30 patients in the treatment were given Shoutai Wan for 3 months, the same treatment was accepted after intrauterine pregnancy, all stopped in 12 weeks of pregnancy; 30 patients in the control were given aspirin and prednisone, lasting for 3 months, chorionic gonadotropin and progesterone were accepted after intrauterine pregnancy, all stopped in 12 weeks of pregnancy. Results: EmAb negative rate in the treatment was 83.3%, better than 60.0% in the control (P0.05). Conclusion: The Shoutai Wan showed obvious effects on eliminating EmAb in ERSA patients, and was better for improving pregnancy results. 【Keywords 】 Immunity; Recurrent spontaneous abortion; TCM medicine therapy doi:10.3969/j.issn.1674-7860.2014.32.004 连续发生 3 次或 3 次以上的自然流产称为复发性流产 堕，甚或如期而堕，腰酸膝软，四肢不温，头晕耳鸣，舌淡， （RS [1] [2] 苔白，脉沉弱。 A ） ，发病率占全部妊娠的 5% 。85%RSA 发生于 [3] 1.3 治疗方法 妊娠早期（孕 12 周内） ，称为反复性早期流产（ERSA ）。 RSA 的病因复杂，目前尚未完全明确，研究发现其与遗传、 1.3.1 中药治疗组 解剖、内分泌、感染、免疫等多因素有关。在不明原因的