临床病理参数的关系.pdfVIP

现代妇产科进展 2001 年 9 月第 10 卷第 5 期 　Prog Obstet Gynecol ,Sept. 2001 ,Vol. 10 ,No. 5 ·论著· Ki67 抗原在卵巢肿瘤组织中的表达及与 临床病理参数的关系 刘培淑 ,李爱华 ,董瑞英 ,孙丽美 ( 山东大学齐鲁医院妇产科 ,济南 　250012) 【摘要】　目的:探讨卵巢肿瘤中增殖细胞相关核抗原 Ki67 的表达及意义。方法 :采 用流式细胞术检测 Ki67 抗原在 52 例卵巢肿瘤组织中的表达。结果 :卵巢癌组织中 Ki67 ( ) ( ) 表达显著高于卵巢良性肿瘤 P 001 。Ki67 的表达随组织学分级 P 001 、临床分期 ( ) ( ) P 005 的升高而增加。Ki67 与卵巢癌肿瘤大小呈正相关 r = 0499 , P = 0006 。结 论 :Ki67 与卵巢癌的组织学分级、临床分期及肿瘤大小有关。 【关键词】　抗原 ,Ki67 ;卵巢肿瘤 ;流式细胞术 ;病理学 ,临床 ( ) 中图分类号:R73731 　文献标识码 :A 　文章编号 :1004 - 7379 2001 05 - 0362 - 02 Study on the expression of Ki67 antigen in ovarian tumors :Correlations of clinical and patho logical parameters. Liu Peishu ,Li Aihua ,Dong Ruiying , et al . Department of Obstetrics and Gyne cology , Qilu Hospital of Shandong University ,Jinan 250012 【Abstract 】　Objective :To study the expression of Ki67 in human ovarian tumors. Methods : The expressions of proliferation cell nuclear antigen Ki67 were measured in 32 cases of ovarian can cer tissues and 20 cases of benign ovarian tumor tissues using flow cytometry. Results : The expres sion of Ki67 in ovarian cancer was higher than that in benign ovarian tumor ( P 001) The ex pression of Ki67 increased with histological grade ( P 001) and clinical stage ( P 005) . There was a positive correlation between Ki67 expression and tumor size ( r = 0 . 499 , P = 0 . 006) . Con clusion :Ki67 is correlated with histological grade , clinical stage and tumor size in ovarian cancer. 【Key words 】　Antigen ,Ki67 ;Ovarian neoplasms ;Flo