卡铂在大输液中稳定性地研究.pdfVIP

卡铂在大输液中稳定性的研究 1 2 胡瑞颖 魏丽停 1 瑞安市人民医院 325200 2 温州医学院 325035 [摘要] 目的 考察注射用卡铂与不同包装的5%葡萄糖注射液 5% GS 10%葡萄糖注射液 10% GS 0.9%氯化钠注射液 0.9%NS 配伍的稳定性 方法 分别观察及测定配伍液于室温 下 4h 内的外观 pH 值及不溶性微粒的变化 并采用高效液相色谱法测定其含量变化 结果 在 室温条件下 注射用卡铂与不同包装的三种输液配伍后4h 内 其外观 pH 值 含量均无明显变化 不溶性微粒有所增加 尤其是10 25μm 的微粒数增加明显 结论 在室温条件下 4h 内 注射用 卡铂可与5%葡萄糖注射液 10%葡萄糖注射液 0.9%氯化钠注射液配伍使用 其中在5%葡萄糖注 射液中最稳定 最好不要溶于0.9%氯化钠注射液中 [关键词] 注射液卡铂 输液 稳定性 Research on the Stability of Carboplatin in Infusion HU Ruiying1 WEI Liting2 1 Ruian People’s Hospital, Zhe Jiang Ruian 325200 2 Wenzhou Medicine College, Zhe Jiang Wenzhou 325035 [ABSTRACT] OBJECTIVE: To study the stability of carboplatin for injection when mixed with 5% glucose injection(5%GS), 10% glucose injection(10%GS), 0.9%NaCl injection (0.9%NS) of different packing. METHODS: The appearance the pH value and the insoluble particles of the mixture solution under room temperature within 4 hours were observed,the contents change of which were determined by HPLC. RESULTS: Under room temperature,no significant changes were found in the appearance,the pH value and the countents in the mixture of carboplatin for injection and other 3 infusion fluid of different packing,the insoluble particles was increased, 10 25µm was increased abviously above all. CONCLUSION: carboplatin for injection can be mixed with the 5% glucose injection,10% glucose injection,0.9%NaCl injection for use under room temperature within 4 hours.And it is stablest in 5% glucose injection,should better not to dissolve in 0.9%NaCl injection. [KEY WORDS] Ca