血清超敏C反应蛋白与心血管危险因素及QT间期的关系_医学论文.docVIP

血清超敏C反应蛋白与心血管危险因素及QT间期的关系_医学论文 血清超敏C反应蛋白与心血管危险因素及QT间期的关系_医学论文 作者:赵小元，米杰，丁秀原，侯冬青，张志坤，程红 【摘要】 目的 在中年自然人群研究血清超敏C反应蛋白（hs-CRP）与心血管危险因素及QT间期的关系。方法 对344例“宫内发育与成人疾病”队列人群（男183例，女161例，年龄47～53岁）的身高、体重、血压、心电图、血糖、血脂及血清hs-CRP等进行测定。采用Bazett公式计算校正的心电图QT间期（QTc），用SPSS10.0软件进行数据统计分析。结果 由低至高的血清hs-CRP四等分组的心血管危险因素（BMI、血压、空腹血糖、HDL-C）组间差异有显著性（均为P＜0.001）TC、TG、LDL-C的组间差异分别为P=0.032，P=0.023，P=0.016，四组心血管危险因素聚集检出率分别为32.9％，50.6％，62.8％，70.9％（χ2=28.20，P＜0.001）。血清hs-CRP水平与QT间期无明显相关（F值=0.103，P值=0.749），但在女性群体似有联系（F值=5.047，P=0.026）。结论 血清hs-CRP与心血管危险因素（BMI、血压、血糖和血脂）呈正相关关系，与QT间期的关系还需要进一步的研究明确。 【关键词】 超敏C反应蛋白；心血管疾病；危险因素；QT间期 Associations of the serum high-sensitive C-reactive protein with cardiovascular risk factors and QT interval 【Abstract】 Objective To study the associations of the serum high-sensitive c-reactive protein (hs-CRP) with cardiovascular risk factors and QT interval in Chinese adult population.Methods Totally，344 adults (183 men and 161 women ) aged 47～53 from the study cohort of fetal origin of adult disease were recruited in the study for clinic examinations，involving anthropometry and measurements of blood pressure，fasting and 2 hr plasma levels of glucose and insulin，serum lipid profile，hs-CRP.A standard 12 lead ECG were recorded and the corrected QT(QTc) was calculated accordingly by Bazett formula.The statistical data were analysed by SPSS 10.0.Results There were significant associations between serum hs-CRP and cardiovascular risk factors ( BMI，blood pressure，fasting plasma levels of glucose，HDL-C，TC，TG，LDL-C) and P＜0.001 or P≤0.032 respectively，and the rates of clusterily of cardiovascular risk factors were 32.9％，50.6％，62.8％，70.9％(χ2=28.20，0.001) from the lowest to the highest quartile of hs-CRP level respectively .There was association between serum hs-CRP level and QT interval in women only (F=5.047，P=0.026).Conclusion There was a significant relationship between hs-CRP and cardiovascular risk factors in the Chinese middle-aged population，the association between hs-CRP and Q