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AACAP OFFICIAL ACTION
Practice Parameter for the Assessment and
Treatment of Children and Adolescents With
Schizophrenia
Jon McClellan, M.D., Saundra Stock, M.D., AND the American Academy of Child
and Adolescent Psychiatry (AACAP) Committee on Quality Issues (CQI)
This Practice Parameter reviews the literature on the assessment and treatment of children and
adolescents with schizophrenia. Early-onset schizophrenia is diagnosed using the same criteria as in
adults and appears to be continuous with the adult form of the disorder. Clinical standards suggest
that effective treatment includes antipsychotic medications combined with psychoeducational,
psychotherapeutic, and educational interventions. Since this Practice Parameter was last published
in 2001, several controlled trials of atypical antipsychotic agents for early-onset schizophrenia have
been conducted. However, studies suggest that many youth with early-onset schizophrenia do not
respond adequately to available agents and are vulnerable to adverse events, particularly metabolic
side effects. Further research is needed to develop more effective and safer treatments. J. Am. Acad.
Child Adolesc. Psychiatry, 2013;52(9):976–990. Key Words: schizophrenia, psychosis
chizophrenia portends substantial morbidity In PubMed, the search strategy from the
Sand suffering to those afflicted and their Cochrane Review Group on schizophrenia was
families. Schizophrenia spectrum disorders used (see below), yielding 282,328 results. This was
often first present during adolescence and rarely in refined to reflect treatment studies and reviews
childhood. Since the last Practice Parameter for the with
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