铜绿假单胞菌的药敏试验结果及耐药性分析_医学论文.docVIP

铜绿假单胞菌的药敏试验结果及耐药性分析_医学论文 铜绿假单胞菌的药敏试验结果及耐药性分析_医学论文 【摘要】 分析我院2008年1月-2009年12月份临床标本中分离出的115株铜绿假单胞菌对常用抗生素的药敏试验结果以及耐药趋势，为临床治疗铜绿假单胞菌感染提供参考。方法 用合肥恒星HX-21细菌鉴定药敏分析仪进行细菌鉴定和药敏试验，检测115株铜绿假单胞菌对临床常用抗生素的敏感性。结果 1358份临床标本中共分离出115株铜绿假单胞菌，铜绿假单胞菌对亚胺培南、阿米卡星、哌拉西林、头孢他啶及环丙沙星的敏感率较高，而对头孢噻肟、庆大霉素、复方新诺明、氨苄西林等抗生素已表现出较高的耐药性。而且耐亚胺培南铜绿假单胞菌比例也日渐增高。结论 近年来，铜绿假单胞菌的分离率已经很高，多重耐药菌日趋增多，耐药机制复杂。因此，加强铜绿假单胞菌对常用抗生素的药敏试验监测可为临床提供最新的流行病学，尽量减少临床经验用药，避免盲目和滥用抗生素。 【关键词】 铜绿假单胞菌 药敏试验 耐药趋势 抗生素 【Abstract】 Purpose It aims to analyze the drug susceptible experiment results and the drug resistant tendency of the commonly-used antibiotics under the influence of 115 pseudomonas ageruginosa, which were isolated from our hospital’s clinical specimen between January 2008 and December 2009. And meanwhile, it is expected to offer reference for curing pseudomonas ageruginosa infection in clinic. Usage method It utilizes HX-21 drug susceptible analysis instrument for bacterial appraisal of Hefei Hengxing Company to identify bacteria and carry out drug susceptible experiment, and then to check the susceptibility of the commonly-used clinical bacteria under the effect of 115 pseudomonas ageruginosa. Findings Among the 115 pseudomonas ageruginosa isolated from 1358 clinical samples, pseudomonas ageruginosa are found to be more sensible to amikacin, piperacillin, ceftazidime and ciprofloxacin, but show its drug resistance towards some antibiotics, such as cefotaxime, gentamicin, SXT and ampicillin. Plus, the proportion of pseudomonas ageruginosa resistant to imipenem is also increasing. Conclusion In recent years, the isolation rate of pseudomonas ageruginosa has been high. Multidrug-resistance bacteria are increasing and resistance mechanisms are complex. Thus, such drug susceptible experiment detest by combining Pseudomonas ageruginosa with commonly used antibiotics can provide the newest epidemic study for clinical medicine, help to reduce the use of medicine as much as possible, and avoid the abuse of antibiotics. 【Key words】 P