壳聚糖涂层对Mg-6%Zn-10%Ca3（PO4）2植入材料生物相容性的影响.pdfVIP

Trans. Nonferrous Met. Soc. China 25(2015) 824−831 Effects of chitosan coating on biocompatibility of Mg−6%Zn−10%Ca (PO ) implant 3 4 2 1 2,3 1,2 3 Jun ZHAO , Liang-jian CHEN , Kun YU , Chang CHEN , 1 1 1 1 Yi-long DAI , Xue-yan QIAO , Yang YAN , Zhi-ming YU 1. School of Materials Science and Engineering, Central South University, Changsha 410083, China; 2. State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China; 3. The Third Xiangya Hospital, Central South University, Changsha 410083, China Received 16 April 2014; accepted 31 October 2014 Abstract: A Mg−6%Zn−10%Ca (PO ) composite with a chitosan coating was prepared to study its in vivo biodegradation 3 4 2 properties. The chitosan dissolved in a 0.2% acetic acid solution was applied on the surface of Mg−6%Zn−10%Ca (PO ) composite 3 4 2 specimens and solidified at 60 °C for 30 min to form the coating. The cytotoxicity evaluation of chitosan coated specimens is at level 0, which indicates that such coating is safe for cellular applications. The in vivo tests of chitosan coated composite show that the concentration of metal ions from the composite measured in the ve