索利那新对神经源性逼尿肌过度活动的效果观察①.pdfVIP

中国康复理论与实践2013年12月第19卷第12期ChinJRehabilTheoryPract,Dec.2013,Vol.19,No.12 - 1111 - DOI: 10.3969/j.issn. 1006-9771.2013.12.004 ·专题 · 索利那新对神经源性逼尿肌过度活动的效果观察① 陈国庆，廖利民，吴娟，田钰 [摘要] 目的 评价索利那新治疗神经源性逼尿肌过度活动的有效性和安全性。方法 选取神经源性逼尿肌过度活动患者50 例，口服索利那新5 mg/d ，记录服药前，服药后2 周、12周的排尿日记以及患者感知膀胱症状量表评分(PPBC-S) ，并记录不良反 应。结果 治疗2 周、12周后每次导尿量由服药前的(224.2± 15.7) ml 增加到(302.6±23.3) ml 和(301.3±21.1) ml (P0.05) ；每天漏尿量 由服药前的(753.9± 121.7) ml 减少到(444.1± 87.1) ml 和(449.1± 89.2) ml (P0.05) ；PPBC-S 评分由服药前的(5.12±0.072) 降低到(4.36± 0.073)和(4.36±0.068)(P0.05) 。有3 例(6%)患者出现口干，无患者诉眼干、视物模糊。结论 索利那新治疗神经源性逼尿肌过度活 动安全有效，可以增加每次导尿的导尿量，减少漏尿量，且副作用小，能明显改善患者生活质量。 [关键词] 神经源性逼尿肌过度活动；索利那新；有效性；安全性 Efficacy and Safety of Solifenacin in Neurogenic Detrusor Overactivity CHEN Guo-qing, LIAO Li-min, WU Juan, et al. Capital Medi- cal University School of Rehabilitation Medicine; Department of Urology, Beijing Boai Hospital, China Rehabilitation Research Centre, Beijing 100068, China Abstract: Objective To assess the efficacy and safety of solifenacin in patients with neurogenic detrusor overactivity (NDO). Methods 50 patients with NDO received solifenacin 5 mg/d. During the treatment period, the voiding diary, Patient Perception of Bladder Condi- tion-Scale (PPBC-S) and side effects were recorded. Results 2 weeks and 12 weeks later, the volume of the catheterization every time in- creased from (224.2± 15.7) ml at baseline to (302.6± 23.3) ml and (301.3± 21.1) ml (P0.05); the volume of leakage every day decreased from (753.9± 121.7) ml to (444.1± 87.1) ml and (449.1± 89.2) ml (P0.05); PPBC-S score decreased from (5.12±0.072) to (4.36±0.073) and (4.36±0.068) (P0.05). There were 3 cases (6%) with dry mouth, and no patients complained dry eyes and blurred vision. Conclusion Solif- enacin is