复方丹参滴丸联合奥美拉唑治疗老年胃溃疡疗效观察_临床医学论文.docVIP

复方丹参滴丸联合奥美拉唑治疗老年胃溃疡疗效观察_临床医学论文 复方丹参滴丸联合奥美拉唑治疗老年胃溃疡疗效观察_临床医学论文 【摘要】 目的 研究复方丹参滴丸与奥美拉唑联合治疗老年胃溃疡的疗效。方法 将86例55～73岁的胃溃疡患者，分治疗组45例，口服复方丹参滴丸250 mg，tid，奥美拉唑20 mg，bid；对照组41例，单纯给予奥美拉唑20 mg，bid，疗程均4周。记录症状变化和不良反应，4周治疗结束时复查胃镜。结果 4周末，治疗组疼痛消失率为86.6%，高于对照组的68.3%；治疗组溃疡愈合率为73.3%，高于对照组的53.7%；治疗组Hp转阴率大于对照组Hp转阴率，但差异无显著性；两组的胃肠道不良反应亦较少，且症状轻；6个月后，治疗组溃疡复发率16.0%，明显低于对照组的38.9%。结论 复方丹参滴丸联合奥美拉唑治疗老年胃溃疡疗效较好。 【关键词】 胃溃疡; 复方丹参滴丸；奥美拉唑；老年人 　　Abstract: Objective The curative effect of gastric ulcer in the aged patients with compound Danshen dripping pills in combination with omeprazole were investigated. Methods 85 patients with gastric ulcer between 55～73-years-old were randomized into therapeutic group (45 cases, treated with compound Danshen dripping pills three times a day, omeprazole 20mg twice daily ) and control group (41 cases, treated with omeprazole 20 mg twice a day). After 4 weeks of treatment, patients were rechecked with gastroscopy. Results The pain relief rate and ulcer healing rate in therapeutic group after treatment was 86.6% and 73.3% respectively, which were higher than control group (68.3% and 53.3% respectively). The negative rate of H. pylori in therapeutic group is better than that in the control group, but there was no significant difference. The side effects were relieved in both groups. After 6 months, the recurring rate of gastric ulcer of the therapeutic group was 16.0%, which was lower than that in the control group (38.9%). Conclusion The treatment of gastric ulcer in the aged patients by compound Danshen dripping pills and omeprazole has better effect. 　　Key words : gastric ulcer ; compound Danshen dripping pills; omeprazole ; aged patients 　　复方丹参滴丸主要药理作用是活血化瘀，普遍用于防治心血管疾病，但在医疗实践中发现它还可应用于治疗慢性肝病、眩晕、脑梗死、外踝关节扭伤等多种疾病，在治疗胃肠疾病也有少量的报道［1-4］。复方丹参滴丸可以改善老年人胃黏膜血供，能促进细胞再生和胃黏膜愈合［1］。笔者用复方丹参滴丸与奥美拉唑联合治疗老年人的消化性溃疡,取得了明显的临床疗效。 　　1 资料与方法 　　1.1 一般资料 　　选择2002年1月～2005年1月间经胃镜检查确诊胃溃疡(GU)或十二指肠球部溃疡(DU)的活动期老年患者86例(其中55～60岁38例，61～65岁30例，65～70岁12例，71～73岁6例),其中男54例,女32例。患者入选前1周内未用过抗菌素，未进行过特殊抗溃疡系统治疗