复方女真丹颗粒镇痛抗炎作用研究_临床医学论文.docVIP

复方女真丹颗粒镇痛抗炎作用研究_临床医学论文 复方女真丹颗粒镇痛抗炎作用研究_临床医学论文 作者：徐秀娟 庞永彩 杜亚伟 【摘要】 　　目的 观察复方女真丹颗粒镇痛抗炎作用。方法 采用醋酸和热板致痛法观察复方女真丹颗粒的镇痛作用；采用二甲苯致小鼠耳肿胀、角叉菜胶致大鼠足肿胀炎症模型观察复方女真丹颗粒的抗炎作用。结果 复方女真丹颗粒1.0、0.5、0.25 g/kg可明显减少醋酸所致疼痛模型小鼠的扭体次数（0.01,0.05）。1.0、0.5 g/kg在给药后60 min可明显提高热板致小鼠疼痛阈值（均0.05），0.25 g/kg组则在给药后120 min痛阈值明显提高（P＜0.05）。复方女真丹颗粒1.0、0.5、0.25 g/kg对二甲苯引起的小鼠耳肿胀有明显的抑制作用（0.01,P＜0.05）；复方女真丹颗粒1.8、0.9 g/kg对角叉菜胶致大鼠足趾肿胀在致炎后4 h开始出现抑制作用（0.01,0.05），6 h作用最明显（0.01），阿司匹林0.2 g/kg在致炎后2 h开始出现抑制作用（0.05），4 h和6 h作用更明显（均0.01）。结论 复方女真丹颗粒具有镇痛和抗炎作用。 【关键词】 复方女真丹颗粒；疾病模型, 动物;抗炎剂(中药)；药理学；镇痛；抗炎 　　Study of Nvzhendan Granula for analgesic and antiinflammation 　　【Abstract】 Objective To investigate the analgesic and antiinflammation effects of Nvzhendan Granula. Methods The analgetic effect was demonstrated using pain models induced by acetic acid and hot board on mice. The Nvzhendan Granula antiinflammatory effect was demonstrated in rats using inflammatory models including auricle edema induced by xylene in mice,and paw edema induced by carrageenin. Results Nvzhendan Granula at 1.0 g/kg,0.5 g/kg and 0.25 g/kg doses could obviously decrease the frequency of writhes by acetic acid in mice (0.01，0.05).The incubation period of pain induced by hot stimulation in mice were prolonged after 60 min at 1.0 g/kg、0.5 g/kg dose, so did after 120 min at 0.25 g/kg dose in mice (0.05).NvzhendanGranula at 1.0,0.5 and 0.25 g/kg doses had markedly inhibitory effect on xylene-induced auricle edema in mice. The paw edema induced by carrageenin were inhibited at 4h at 1.8 g/kg, 0.9 g/kg and 0.45 g/kg dose(0.01,0.05), and the effect achieve the top level at 6 h in mice (0.01).Acetosal at 0.2 g/kg doses had inhibitory effect at 2 h on inflammation in mice(P＜0.05)，and significant effect at 4 h,6 h(P＜0.01). Conclusion The results suggest that Nvzhendan Granula has the analgesic and antiinflammatory effects. 　　【Key words】 Nvzhendan Granula;Animal model;Analgesic;Antiinflammatio 　　复方女真丹颗粒为复方中药制剂，由川芎、白芍药、香附、肉桂等12味中药组成。现观察其对醋酸和热板所致小鼠疼痛模型、二甲苯致小鼠耳肿胀和