复方甘草酸苷联合阿昔洛韦治疗带状疱疹的疗效观察_临床医学论文.docVIP

复方甘草酸苷联合阿昔洛韦治疗带状疱疹的疗效观察_临床医学论文 复方甘草酸苷联合阿昔洛韦治疗带状疱疹的疗效观察_临床医学论文 【摘要】 目的　　观察复方甘草酸苷联合阿昔洛韦治疗带状疱疹的疗效。方法　　将120例带状疱疹患者随机分为治疗组和对照组各60例。治疗组予阿昔洛韦联合复方甘草酸苷静脉滴注，对照组予泛昔洛韦口服，疗程均为7天。结果　　治疗后症状、体征消退时间治疗组明显优于对照组（0.05）；后遗神经痛发病率治疗组（11.67％）明显低于对照组（31.67％）。 结论　　复方甘草酸苷联合阿昔洛韦疗法治疗带状疱疹疗效显著。 【关键词】 阿昔洛韦 复方甘草酸苷 带状疱疹 Observation of clinical efficacy of acyclovir combined with compound glycyrrhizin in the treatment of herpes zoster LIU Li, GUO jian, YANG Bai-yan, et al. Department of Dermatology, The First People’s Hospital of Yibin, Cichuan 644000, China 【Abstract】　　Objective　　 To observe the clinical efficacy of acyclovir combined with compound glycyrrhizin in the treatment of herpes zoster. Methods　　120 patients with herpes zoster were randomly divided into treatment group（n=60） and control group（n=60）. The treatment group was treated with acyclovir combined with compound glycyrrhizin iv drip, while the control group was given orally famciclovir. The course of treatment was 7 days. Results　　The regression time of the symptoms and signs in the treatment group was significantly shorter than that of the control group （0.05）.The incidence rate of residual neuralgia in the treatment group was significantly lower than that of the control group. Conclusion　　Acyclovir combined with compound glycyrrhizin has significantly therapeutic effect in the treatment of herpes zoster . 【Key words】　　acyclovir;compound glycyrrhizin;herpes zoster 　　　　带状疱疹是由水痘－带状疱疹病毒引起的急性疱疹性皮肤病，临床上表现为带状分布成簇的皮疹和神经痛，老年患者疼痛常较剧烈，且皮疹消退后常会遗留神经痛和其他并发症［1，2］。笔者于2005年1月～2008年2月共收集了120例带状疱疹患者治疗资料，采用复方甘草酸苷联合阿昔洛韦治疗带状疱疹患者60例，取得满意疗效，现报道如下。 1　　资料与方法 1.1　　一般资料　　共入选120例，均为本科门诊患者。按其就诊顺序，分为治疗组和对照组，奇数为治疗组，偶数为对照组，各60例。纳入标准：（1）有带状疱疹的典型临床症状和体征；（2）病程均小于5天；（3）4周内未内服或外用过抗病毒药及免疫调节剂。排除标准：（1）对阿昔洛韦及其衍生物过敏者；（2）皮损并发细菌感染者；（3）已知有严重的免疫功能低下，或需长期服用糖皮质激素及免疫抑制剂者；（4）有重要脏器功能受损者；（5）妊娠期及哺乳期妇女；（6）中途退出试验者；（7）年龄lt;18岁者。治疗组男35例，女25例；年龄51±12.2岁；病程3.05±1.3天；皮损分布于胸背部26例，腰腹部19例，头面部9例，四肢6例。对照组男31例，女29例；年龄54±9.5岁；病程3.21±1.46天；皮损分布于胸背部23例，腰腹部21例，头面部10例，四肢6例。两组患者的年龄、体重、病程、症状和体征积分比较