复方痛风胶囊治疗痛风的临床及实验研究_临床医学论文.docVIP

复方痛风胶囊治疗痛风的临床及实验研究_临床医学论文 复方痛风胶囊治疗痛风的临床及实验研究_临床医学论文 作者：李从容，李东凌，周继刚，沈静，余军 【摘要】 　　目的观察复方痛风胶囊对临床痛风患者的治疗作用，以及其对高尿酸血症小鼠血尿酸的影响和镇痛作用。方法选取痛风急性期病人，分别给予秋水仙碱加别嘌呤醇治疗，以及复方痛风胶囊治疗7d。观察临床积分、血尿酸、红细胞沉降率和C反应蛋白。小鼠用复方痛风胶囊灌胃7d后，以次黄嘌呤600mg/kg腹腔注射和烟碱100mg/kg灌胃诱导高尿酸血症模型，30 min后取血，观察药物对血尿酸的影响。以热板法观察复方痛风胶囊的镇痛作用。结果复方痛风胶囊改善痛风患者关节的疼痛和肿胀情况，降低血尿酸、血红细胞沉降率和C反应蛋白水平；复方痛风胶囊能显著降低高尿酸血症小鼠模型的血尿酸量，对热板致痛具有明显镇痛作用。结论复方痛风胶囊能降低血尿酸、抗炎镇痛从而产生对痛风的治疗作用。 【关键词】 中草药 痛风 尿酸 镇痛 小鼠 　　Abstract：ObjectiveTo observe the effect of Complex Gout Capsule on gout patient, serum uric acid level and its analgesic effect in mice.MethodsAcute gout patients were administered colchicina and allopurinaol, or Complex Gout Capsule, for 7 days, respectively. The clinical integral scores, serum urine acid, ESR and C-reactive protein were detected. 　After administration of Complex Gout Capsule for 7 days，the mice were injected with hypoxanthine (600mg/kg) and niacin (100 mg/kg) to establish hyperuricemia model . And then their blood was taken after 30 min to determine uric acid in serum．In addition，the analgesic effect of Complex Gout Capsule was observed with hot plate method. ResultsAdministration of Complex Gout Capsule ameliorated pain and joint swelling scores, decreased serum urine acid, ESR and C-reactive protein in acute gout patients. Complex Gout Capsule treatment significantly reduced serum uric acid level hyperuricemia model mice, and showed analgesic effect in hot plate method. ConclusionComplex Gout Capsule can reduce serum uric acid, and possesses anti-inflammatory and analgesic effects, which suggest Complex Gout Capsule is an effective anti-gout drug. 　　Key words： Chinese herbal; Gout; Serum uric acid; Analgesic effects; Mouse 痛风是由于嘌呤代谢紊乱和（或）尿酸排泄障碍所致血尿酸增高的一组异质性疾病。其临床特点是高尿酸血症、痛风性急性关节炎反复发作、痛风石沉积、特征性慢性关节炎和关节畸形，常累及肾引起慢性间质性肾炎和肾尿酸结石形成。病人大多为40岁以上的男性，女性多见于更年期后发病。随着人民生活水平的提高，高尿酸血症所致痛风的发生率日益增加。目前全球痛风病患者高达1.2亿，我国痛风病患者超过4000万人，且发病率高于世界平均水平。痛风及其并发症能降低人们的生活质量，严重危害人们健康，但是迄今没有理想的治疗痛风的药物。秋水仙碱是目前临床上常用的治疗痛风的药物，但其严重的副作用，如恶心、呕吐、水样腹泻、肝细胞损伤、骨髓抑制、脱发