大孔径速降解磷酸钙骨水泥的制备_临床医学论文.docVIP

大孔径速降解磷酸钙骨水泥的制备_临床医学论文 大孔径速降解磷酸钙骨水泥的制备_临床医学论文 【摘要】 研究造孔剂蔗糖对磷酸钙骨水泥性能的影响。［方法］根据蔗糖的比例(蔗糖／(蔗糖+CPC粉末)0%、10%、20%、30%、40%共分5组，从力学强度、水化反应、物相晶体组成及微观结构、体内降解，分析其性能。［结果］随造孔剂蔗糖比例的增加，材料的力学性能下降，大孔率和总孔率增加，各组间有显著差异(0.01)。30%CPC总孔率、大孔率为62.9%、22.8%，而40%组各为70.3%和39.7%，但其抗压强度从5.4 MPa降至2.6 MPa。XRD提示造孔剂可促进样品羟基磷灰石的转化率。体内降解试验表明：在1个月、3个月，30%CPC的降解率与0%CPC存在明显差异(0.01)。提示大孔CPC可加快其降解和吸收。［结论］30%CPC具有适当的大孔率、总孔率和力学强度，能加快材料的降解，因此，30%CPC可用于非负重部位骨缺损的修复。 【关键词】 磷酸钙骨水泥 大孔 降解 Abstract: ［Objective］To investigate the effect of an effervescent-sucrose on the properties of calcium phosphate cement. ［Method］The sucrose particles were mixed with CPC powder at sucrose/(sucrose+CPC powder) mass percentage of 0%, 10%,20%, 30%, 40%.The samples were characterized by compressive strength, X-ray diffraction, SEM techniques and degradation in vivo.［Result］The samples decreased on the mechanical properties and increased on the rate of macropore and total porosity, they were effected significantly among groups by added effervescent( 0.01) .The rate of macropore and total porosity of 30%CPC had 22.8%, 62.9%,respectively;40%CPC had 39.7%,70.3%,respectively, however, it s compressive strength significantly decreased from 5.4MPa to 2.6MPa. XRD indicated the transformation of apatite was promote by increasing the effervescent.The biodegradation of samples had significant difference between 0%CPC and 30%CPC(0.01),it demonstrated the CPC with macropore can promote degradation and resorption.［Conclusion］30%CPC has proper compressive strength, the rate of macropore and total porosity, and accelerates biodegradation and resorption, therefore, 30%CPC could be novel biomaterials as an endo steal implant. Key words：calcium phosphate cement； macropore； degradation 磷酸钙骨水泥(calcium phosphate cement CPC)自1986年问世以来，因其具有良好的生物相容性、优良的骨传导性，能被新生骨组织替代，可自行固化和任意塑形等优点于1996年被FAD批准临床应用。随后在骨组织领域得到广泛的推广和应用。然而CPC植入机体后，降解缓慢，骨替代和再吸收时间长，影响了机体骨组织再生，国内外已在制作有孔CPC以促进其降解方面作了一些尝试［1～4］。本实验用蔗糖为造孔剂，制作了一种大孔径骨水泥。这种大孔能促进骨水泥在体内的降解和吸收，促进骨组织向骨水泥内部生长，加快新骨的替代过程。现报道如下。