小儿抽动障碍与A组溶血性链球菌感染抗基底神经节抗体关系_临床医学论文.docVIP

小儿抽动障碍与A组溶血性链球菌感染抗基底神经节抗体关系_临床医学论文 小儿抽动障碍与A组溶血性链球菌感染抗基底神经节抗体关系_临床医学论文 作者：李冰，陈黎，黄铁栓，廖建湘，胡雁，扬亚平，翟洪顺 【摘要】 目的 探讨慢性抽动症和多发性抽动症与链球菌感染抗基底节抗体的关系。方法 采用酶联免疫吸附试验方法随机测定30例小儿抽动症血清抗基底节抗体(IgG)，并与20例对照组对比；同时测定二组病儿的链球菌感染证据，ASO(抗链球菌溶血素O)，ADNaseB(抗链球菌脱氧核糖核酸酶B)。 结果 病例组ASO阳性率为40%(12/30)，对照组为15%(3/20)，二组差异没有统计学意义(Pgt;0.05)。病例组ADNaseB阳性30.0%(9例)，对照组ADNaseB阳性5.0%(1例)，病例组和对照组ADNaseB阳性率之间的差异有统计学意义(0.05)。病例组抗基底节抗体阳性率30%(9/30)，对照组15%(3/20)，两组抗基底节抗体阳性率的差异无统计学意义(Pgt;0.05)。ADNaseB阳性和抽动症有统计学关联(P = 0.057)，其OR值为8.143(OR 95% CI：0.942~70.409)。 结论 部分小儿抽动症的病因可能与链球菌感染有关，尤其应注意检测ADNaseB。抗基底节抗体与链球菌感染的关系尚不肯定。 【关键词】 抽动症；链球菌感染；抗基底节抗体 ［Abstract］ Objective To study the relationship between chronic tic disorder/tourette syndrome and Group A streptococcal infection/antibodies to human basal ganglia.Methods Conducted enzyme-linked immunosorbent assay to detect antibodies to human basal ganglia of serum (IgG) of 30 children with tic disorders，which was compared with 20 non-infected disease children；and detected the streptococcal infection evidence，ASO (anti-streptolysin O)，ADNaseB (anti-DNase B) between the two groups of diseased children.Results The positive rate of ASO for the group of infected children was 40%(12/30).The positive rate of ASO for the comparison group was 15%(3/20).The difference between the two groups was statistically meaningless (Pgt;0.05).The positive rate of ADNaseB for the infected group was 30.0% (9 cases).The positive rate of ADNaseB for the comparison group was 5.0% (1 case).The difference of ADNaseB positive rate between the infected group and the comparison group was statistically meaningful (0.05).The positive rate of antibodies to human basal ganglia for the infected group was 30% (9/30).The positive rate of antibodies to human basal ganglia for the comparison group was 15%(3/20).The difference of positive rates of antibodies to human basal ganglia between the infected group and the comparison group was statistically meaningless (Pgt;0.05).ADNaseB positive rate had statistical relati