活血化瘀方中使药郁金对君药丹参药代动力学的影响的研究.pdfVIP

′06 陕西药物分析学术研讨会 活血化瘀方中使药郁金对君药丹参药代动力学的影响研究 1 2 2 1 1 1 郑晓晖 张丽 陈林 房敏峰 王世祥 郑建斌 (1. 西北大学分析化学研究所，西安 710069; 2.云南民族大学，昆明 650031） 摘要 目的：研究活血化瘀方中使药郁金对君药丹参在气滞血瘀模型家兔体内药代动力学的 影响。方法：制造气滞血瘀模型家兔，丹参组和配伍组分别灌胃给药，反相高效液相色谱法 测定丹参素的血药浓度，DAS 软件对结果进行统计分析。结果：丹参组和配伍组丹参素的 药-时曲线均符合二室开放模型，但配伍组 T1/2α减小，AUC(0 ~ ∞)增加。结论：活血化瘀方 中，使药郁金可促进君药丹参吸收入血，该研究可为“君–使”对药体内作用机制的研究提 供思路。 关键词 丹参 郁金 “君–使”对药 气滞血瘀 Pharmacokinetic effect of Radix Curcumae on Salvia Miltiorrhiza in qi-stagnancy and blood stasis rabbits 1 2 2 1 1 ZHENG Xiao-hui , ZHANG Li , CHEN Lin , FANG Min-feng , WANG Shi-xiang , ZHENG 1 Jian-bin (1. Institute of Analytical Chemistry, Xi’an 710069; 2. Yunnan Nationalities University, Kunming 650031) Abstract Objective: To investigate the pharmacokinetic effect of Radix Curcumae on Salvia Miltiorrhiza from the prescription of “Activating Blood Circulation to Dissipate Blood Stasis” in qi-stagnancy and blood stasis (QSBS) rabbits. Methods: Rabbits were administrated with adrenaline to obtain QSBS rabbits, and then equally divided into two groups. One group was administrated with Salvia Miltiorrhiza and the other was administrated with Salvia Miltiorrhiza coupled with Radix Curcumae . Concentration of Danshensu in plasma was determined by reversed phase high performance liquid chromatography. The data was handled by software of DAS to calculate pharmacokinetic parameters. Results: Danshensu was conformed to be a two-open compartment model in all groups of rabbits. T1/2α was de