颅内动脉瘤主要发病机制研究进展.pdfVIP

∀ 3078∀ 2010 10 16 20M ed ical Recap itu late, O ct 2010, V o.l 16, No. 20 邓青山 ( ) , 李定君 ( ) (, 646000) : R543. 1 : A :( 2010 ) :颅内动脉瘤( IA )是遗传因素和环境因素共同作用的结果, 与遗传基因脑血流动力 [ 3] 学因素血管因素等相关 中遗传因素主要涉及诸多新近发现的与 IA相关的基因, 表达异 , 常会导致局部血管壁产生不同形式的改变及破坏; 持续的血流动力学作用使得血管壁生理结 构紊乱, 诱导血管壁瘤样变化; 血管因素主要涉及炎性反应对血管壁的破坏, 如血管内皮细胞 , 外基质及平滑肌层的完整性被破坏 , : 颅内动脉瘤; 遗传基因; 血流动力学; 炎性反应 ; 5q22~ 31 RecentResearchProgress in the Pathogenesis of Intracranial Aneurysm D EN G Qing shan, LI D ingjun. (D epa rtm en t of N eurosurg ery, the F irst Aff iliated H osp ita l to L u h ouM ed ica l C ol lege, Lu h ou , 646000, China) Abstract: Intracranial aneurysms( IA), characteri ed by a saclikew iden ni g of cranial artery, is a com b ined effect of genetic and environmen tal factors. Recen tly, m any genes have been found to be associated w ith IA. Their abnorm al expression m ay change or even damage local vesselw alls in m any ways; the contin uous effectof hemodynam ics causes vessel th e structural changew alls and lead sa tum orlike change; th e in IA flammatory reaction in local vesselw alls can dam age the in tegrity of vascular endothelial cells, extracellu lar m atrix and smooth muscle layers. A ll of these factors are involved in the form ation of IA. , 1 Key words: In tracran ial aneu rysm; Genetic expression; H em odynam ic factors; Inflamm ation ( m onocyte chem oattractant pro ( intracranial aneurysm s, IA ) te in1, MCP1) MCP1 , , MCP1- /- , , MM Ps, IA