双氢青蒿素衍生物的研究进展_沈丹丹.pdfVIP

DOI :10.14159/j.nki .0441 -3776.2008.09.008 http: 　　　　　　　　　　　2008 9 ·659 · 1, 2 1 ＊ 1, 2 3 ＊ 1 沈丹丹 　沈敏敏 　臧运晓 　杨新潮 　哈成勇 1 ( 　　510650; 2 3 　　100049;　 　　510070) 　　、、 C-10-O , 1997 , , 、、、。 　　　 Progress in Dihydroartemisinin Derivatives 1, 2 1 ＊ 1, 2 3 ＊ 1 Shen Dandan , Shen Minmin , Zang Yunxiao , Yang Xin hao ,Ha Chengyong 1 (Guangzhou Institute of Chemistry, Key Laboratory of Cellulose and Ligno ellulosi s Chemistry, 2 Chinese A ademy of S ien es, Guangzhou 510650;Graduate S hool of the Chinese A ademy of S ien es, Beijing 100049; 3 Guangzhou Bran h Chinese A ademy of S ien es,Guangzhou 510070) Abstract　On the base of two lass stru tures, whi h are monomeri 1, 2, 4-trioxane dihydroartemisinin derivatives in luding ethers, esters, and other heteroatoms groups at C-10, and trioxane dimmers, the syntheses of dihydroartemisinin derivatives were fo used on.The a tivities of dihydroaremisinin derivatives besides antimalarial were dis overed. Keywords　Dihydroartemisinin derivatives, Synthesis, A tivities [1] 。: [2, 3] , , 、, [4 ～9] ; , , , 、、、。 90 %, 1997 、。1997 、 [10] , 。 1　 1.1　 1.1.1　　2 、、、 。1、、、 (BF3 -Et2 O, SnCl4 )(TMSCl )[11～ 13] , 1。 、, 、。 [11] 。3 , 、, (, ), , [14] 。4 、, [15, 16] 。