月桂酯检测方法.pdfVIP

DODECYL GALLATE Prepared at the 46th JECFA (1996), published in FNP 52 Add 4 (1996) superseding specifications prepared at the 41st JECFA (1993), published in FNP 52 Add 2 (1993). Metals and arsenic specifications revised at the 61st JECFA (2003). A temporary ADI established at the 41st JECFA (1993) was deleted at the 46th JECFA (1996) and no ADI allocated. SYNONYMS Lauryl gallate, INS No. 312 DEFINITION Chemical names Dodecyl gallate, n-dodecyl (or lauryl) ester of 3,4,5-trihydroxy-benzoic acid, dodecyl ester of gallic acid, dodecyl 3,4,5-tri-hydroxybenzoate C.A.S. number 1166-52-5 Chemical formula C19H30O5 Structural formula Formula weight 338.45 Assay Not less than 98.5% on the dried basis DESCRIPTION White to creamy-white crystalline odourless solid FUNCTIONAL USES Antioxidant CHARACTERISTICS IDENTIFICATION Solubility (Vol. 4) Insoluble in water; freely soluble in ethanol and ether Melting range (Vol. 4) 95 - 98º after drying Gallic acid Dissolve about 0.5 g of the sample in 10 ml of sodium hydroxide TS and boil for 30 min under nitrogen. Maintaining a stream of nitrogen, cool the mixture and acidify to pH 2-3 with sulfuric acid TS. Filter the precipitate through a sintered glass crucible, wash with a minimum amount of water and then dry at 110ºfor 2 h. The melting point of the gallic acid so obtained is about 240º, with decomposition. TLC separation of gallate Use a thin-layer plate prepared with silica gel G. Prepare a sample solution esters by dissolving 1