川芎嗪局部静脉给药对肢体缺血_再灌注损伤的保护作用.pdfVIP

# 508 # 2006 7 22 7 J Clin An sth siol, July 2006, Vol. 22, No. 7 # # - 方剑 李涛 方晓萍 刘克明 宋晓辉 = -, 59 , 19 ( A ) , 18 ( B ) 22 ( C ) ( T ) 0~ 1 min( T ) 15 0 1 min( T ) 30 min( T ) ( M DA) 2 3 B , T 3 A MDA B ( P 01 05) ; , T 3 MDA (P 01 05) ; T 3 C MDA MDA ( P 01 05) -, -, = -; ; Protection of local intravenous administration of ligustrazine against ischemic reperfusion of limbs Fang Jian , Li Tao , Fang Xiaoping , t al . D partm nt of An sth siology , Zhuhai Hospital of Guang Dong Provinc . s Chin s M dical Hospital , Zhuhai 5 190 15 CHINA = Abstract Objective T o study th prot ction ff ct of local intrav nous administration of ligu- strazin against isch mic r p rfusion of th limbs. Methods Fifty-nin pati nts und rgoing low r limb op rations w r studi d. T h pati nts w r randomly divid d into 3 groups: 19 cas s in group A ( local intrav nous administration) , 18 in group B ( p riph ral intrav nous adm inistration) and 22 in group C ( control) . Blood sampl s w r obt ain d b for fast ning tourniqu t, at 1 and 15 and 30 min aft r r l as of tourniqu t ( r p rfusion) . MDA w as m asur d and com par d. Results MDA aft r 30 min of r p rfusion in group A w as significant ly l ss than that in group B ( P 01 05) . At 30 m in of r p rfusion MDA significant diff r nc s ar s n among group A , B and C ( P 01 05) . At 30 min aft r r p rfusion in group C, MDA in t ourniqu t sit was significantly high r than that in p riph ral v in ( P 01 05) . Conclusion Local intrav nous administ ration of ligust razin has prot ctiv ff ct against isch mic r p rfusion of th limbs, which is mor fficacious than p riph ral intrav nous administration. Th l v l of p riph ral v nous sampl s is diff r nt