葵花护肝片对抗结核治疗ALT异常的预防及其机制探讨.pdfVIP

2008年9月中国·天津 葵花护肝片对抗结核治疗ALT 异常的预防及其机制探讨 刘琼杜德兵彭秋萍陈武(湖北省宜昌市第5-AR．医院，湖北宜昌443003) 摘要 目的探讨葵花护肝片对抗结核药物肝损害的预防作用及其机制。方法231例结核病患者 3个月，I组加用葵花护肝片，Ⅱ组加用还原型谷胱甘肽，Ⅲ组加用肝泰乐。结果A、B、C组3个月内肝 肝损害发生后血清过氧化脂质水平增高，与治疗前及无肝损害者相比较差异有显著性(PO．05)，C组血 清过氧化脂质水平明显高于A组和B组(PO．05o结论抗结核药物所引起的肝损害与体内的脂质过 氧化有关，应用葵花护肝片能显著降低肝损害的发生率。 关键词丙氨酸氨基转移酶结核过氧化脂质葵花护肝片 Thesunflowertheliver resistancetuberculosistotreattheALTunusual and protects piece prevention themechanismdiscussion Du of Third Tuberculosis，The DebingPengQiupingChenWu，Department People’S 443000 To ofall-- ABSTRACT the effectof intreatment Objectiveinvestigate Sunflower-Huganpian preventive ti-tuberculosis liver andthe 231 withtuberculosiswereacci- drug-inducedinjury possibility．Methodspatients dividedintothree sam- dentally groups，GroupA(Huganpiangroup)，78samples，GroupB(Glutathionegroup)，72 1 the threemonthsofanti-tuberculosisA pies，GroupC(Glucuronegroup)，8samples．Inprimal therapy，group added BaddedReduced CaddedGlucurone．ResultsThe inci- Huganpian，group Glutathione，group respective with liver 1 with denceof in Was A，B，C drug-induced 1．5％，9．7％and patientsgroup injury 25．9％．Compared Aand resultshowedno C B，the significant group difference(P0．05)．Whengroupcomparedrespectively衍t}I Aand differencewas