黄芩苷对动脉粥样硬化大鼠凝血酶激活纤溶抑制物水平及血脂、凝血纤溶指标的影响.pdfVIP

王盟差黄荃营Ilf麴然塑搓塑焦太鼠搓查酶邀置红盗控制堑盔垩厘虫脂：凝鱼红渣指拯丝墅喧筮丝翘 黄芩苷对动脉粥样硬化大鼠凝血酶激活纤溶抑制物水平及血脂、 凝血纤溶指标的影响 于 昕 刘向群 陈焕芹 马文健 陈效安 (山东大学齐鲁医院干部保健科，山东 济南250012) (摘要】 普通饲料喂养，其余3组在给予高脂饲料喂养的基础上行主动脉球囊损伤术，喂养4个月，以复制大鼠As模型。用全自动生化仪测定血浆总胆固醇 统平衡、下调TA兀水平等途径干预了AS的形成。 [关键词】动脉硬化；血脂；纤维蛋白原；凝血酶激活的纤溶抑制物；黄芩苷 [中圈分类号】11：541．4 (文献标识码]A(文章编号】lO惦母2眈(2010)22-3299-03 Effectsofbaicalinon,f沦ruln in andthrombin-activatableinhibitortheatheroscle- Hpids，bloodcoagulation，flbrinolysis flbrinolysis rosisrats YU Xin．LIU Xiang-Qun．CHENHuan·Qin．et以 of of DepartmentGeriatrics，QiluHospitalShandongUniversity，Jinan250012，Shandong，China To theeffectsand mechanismsofbaicalinon 【Abstract】Objective possible the investigate 40 Wistarratsweredivided intofour control fedwithnormal model healthy randomly groups：normalgroup(凡=10)anddiet，AS group control inthelastthree werefedwith (n=10)，baicalintherapygroup(n=10)，andpositive group(rt=10)，ratsgroups dietfor16 with 100 weeks．Treatedbacalin simvastatin5 for16weeksinbaicalinthera． mg·k一·d～，and nag·kg～·d“additionally and control from secondweekSerum positive groups the and fibri． PY respectively lipids．bloodcoagulation。fibrinolysis detectedwitllstandard Thelevelsoftotal inhibitor(TAFi)were nolysis enzymaticassays．Results low—densitylipoprotein time(PT)，activatedthromboplastin cholesterol(LDL—C)，prothrombinpartial TAFIint11ethreemodel were thanthoseofnormalcontrol or lev