嘧苯胺磺隆的合成与生物活性.pdfVIP

第54卷第1期 农药 Vol.54, No.1 2015年1月 AGR OCHEMICALS Jan. 2015 柴宝山, 孙旭峰, 崔东亮, 等. 嘧苯胺磺隆的合成与生物活性[J]. 农药, 2015, 54(1): 14-15. 嘧苯胺磺隆的合成与生物活性 崔东亮，刘长令 柴宝山，孙旭峰， 沈阳110021) (沈阳化工研究院有限公司新农药创制与开发国家重点实验室， 摘要：[目的]嘧苯胺磺隆是嘧啶磺酰脲类除草剂，开展该类化合物的研究工作，探索其合成方法并进行生物活性 测定。[方法] 以邻氨基苯甲酸和2- 氨基- 4,6- 二甲氧基嘧啶为起始原料，共经过4步反应合成目标化合物嘧苯胺 磺隆，经核磁验证其结构。[结果] 生物活性测定结果表明该化合物对苘麻具有优异的抑制效果。[结论] 嘧苯胺磺 隆具有优异的除草活性，且对水稻、小麦安全，具有很广阔的应用前景，值得重视。 关键词：嘧苯胺磺隆；合成；除草活性 中图分类号：TQ460.3 文献标志码：A 文章编号：1006- 0413(2015)01- 0014- 02 Synthesis of Orthosulfamuron and Its Bioactivity CHAI Bao- shan, SUN Xu- feng, CUI Dong- liang, LIU Chang- ling (State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co., Ltd., Shenyang 110021, China) Abstract: [Aims] Orthosulfamuron is a pyrimidinylsulfonylurea herbicide. In order to study its derivatives, the synthetic method and herbicidal activities were explored. [Methods ] Orthosulfamuron was synthesized through four steps 1 from 2-aminobenzoic acid and 2-amino-4,6-dimethoxypyrimidine, and its structure was confirmed by H NMR. [Results] The test result shows that orthosulfamuron has good herbicidal activity against Abutilon theophrasti . [Conclusions] Orthosulfamuron showed potent herbicidal activities and safe to rice and wheat, it has a broad