非痴呆型血管性认知功能障碍患者神经心理学特点及石杉碱甲的临床疗效观察.pdfVIP

中国临床神经科学2009 年第 17 卷第5 期 5 10 9, 17 (5) ,510~514 论 著 非痴呆型血管性认知功能障碍患者神经心理学特点 及石杉碱甲的临床疗效观察 江 波，孟晓落，舒刚明，姚存姗，陈玉妹，郭月其 (解放军总医院第一附属医院神经内科100048) 关键词 非痴呆型血管性认知功能障碍；简易智能状态检查量表；画钟试验；石杉碱甲 摘要 目的：探讨非痴呆型血管性认知功能障碍(V CIND)患者的神经心理学特点，观察石杉碱甲对认知功能损害的改 善作用。方法：将64 例VCIND 患者随机分成2 组：常规治疗组和石杉碱甲治疗组；另设健康对照42 例。3 组均进行 简易智能状态检查量表(MMSE)、画钟试验(CDT)测定。VCIND 患者治疗第4 和第8 周时重新测定MMSE 及CDT 并加 以对比。结果：①VCIND 组与健康对照组在CDT 评分、MMSE 总分以及时间定向、地点定向、计算能力、短程记忆、 言语复述、阅读能力、语言表达及图形描绘方面的差异有显著统计学意义(P0.0 1) 。②石杉碱甲治疗的VCIND 患者第 8 周时MMSE 、CDT 评分与治疗前及常规治疗组比较均有明显改善。结论：①CDT 、MMSE 总分及亚项的测评，有 利于早期发现VCIND 患者的认知功能受损。②石杉碱甲可有效改善VCIND 患者的认知功能损害。 Research of the Patients with Vascular Cognitive Impairment no Dementia in Terms of Neuropsychology and the Clinical Study of Huperzine A in the Treatment JIAN G Bo, MEN G X iao-Luo, SH U Gang-Ming, YA O Cun-Shan, CHEN Yu-Mei，GUO Yue-Qi Department of Neurology, the First Affiliated Hospital, General Hospital of PLA, Beij ing 100048, China KEY WORDS vascular cognitive impairment no dementia；mini-mental state examination；clock drawing test ; huperzine A ABSTRACT Aim: To investigate the characteristics of the patients with vascular cognitive impairment no dementia(VCIND) in terms of neuropsychology and to observe the efficacy of huperzine A in treating VCIND. Methods: 64 patients with VCIND and 42 normal controls were examined with the neuropsychological test, including mini-mental state examination(MMSE), clock drawing test (CDT). 64 patients with VCIND were randomly divided into 2 groups: a huperzine A treated group and a control group. The whole course of treatment for each group lasted 8 weeks. MMSE and CDT were examined in the 4th week and 8th week. Results: ①The scores of