甲状腺癌组织中VEGF和VEGF-C的表达及意义.pdfVIP

维普资讯 · 212 · 临床与实验病理学杂志 JClinExpPathol 2005Apr；21(2) 甲状腺癌组织中VEGF和VEGF—C的表达及意义 陈天星，杨宣涛，陈建伟，杨 慧 [摘要] 目的 探讨血管内皮生长因子(VEGF)、VEGF—C在甲状腺癌中的表达及其意义。方法 应用免疫组化S-P法检测 44例甲状腺癌中VEGF、VEGF—C的表达情况 ，并以l7例癌旁正常甲状腺组织作对照。结果 VEGF、VEGF—C在甲状腺癌中 呈高水平表达(88．6％、818％)。VEGF表达随癌组织分化程度的减低而增高，9例死亡病例均为阳性表达；VEGF—C表达随 癌组织分化程度的减低而减低 ，乳头状癌阳性表达(88．9％)高于其它类型，VEGF—C阳性率在有淋巴结转移组(92．0％)明显 高于无淋巴结转移组 (68．4％)(P005)。9例死亡病例中7例为阳性表达 ，且7例同时VEGF呈阳性表达。结论 VEGF、 VEGF—C表达与甲状腺癌病理分型及预后可能有一定关系，VEGF—C与甲状腺癌淋巴结转移密切相关。 [关键词] 甲状腺肿瘤；血管内皮生长因子 ；血管内皮生长因子c [中图分类号] R736，l [文献标识码] A [文章编号] 1001—7399(2005)02—0212—03 Expressionofvascularendothelialgrowthfactor(VEGF)andVEGF-Cinthyroidcancer CHENTian—xing。YANG Xuan—tao，CHENJianwei，YANGHui (DepartmentofPathology，theFirstPeople’SHospitalofYunnanProvince，Kunming 650032，China) [Abstract] Purpose TostudytheexpressionofVEGF，VEGF—Candtheirbiologicalsignificanceinthyroidcancers．Methods Immunohistochemical S—PmethodwasusedtoexaminetheexpressionofVEGFandVEGF—Cin44casesofthyroidcancersand17nor— malthyroidtissuesbesidethe cancer．Results The strongexpression ofVEGF and VEGF—C were displayed in thyroid cancers (88．6％ and81．8％，respectively)．TheexpressionofVEGFwasincreasedwithpoorerdifferentiationofthecarcinomas．Ninedied easeswereallpositiveforVEGF．Onthecontrary．theexpressionofVEGF—C wasdecreasedwithpoorerdifferentiationofcarcinoma． Thepositiveratewassingificantlyhigher(889％)inpapillarythyroidcancerthanthatinothertypes．andalsosignificantlyhigherin caseswithlymphnodemetastases(92．0％)thanthatwithout(68．4％)(P0．05) SevenofninediedcasesexpressedbothVEGF— CandVEGF．Conclusions TheexpressionofVEGF andVEGF—C iscorrelatedwiththepathologicalelassfieationofthyroidcancer anditsprognosis．VEGF—C iscloselyassociatedwithlymphnodemetastases． [Keywords] thyroidneoplasms；vascularendothelialgrowthfactors；vascularendothelialgrowthfactorC 血管生成对肿瘤生长和转移非常重要，肿瘤细 上44例