乳腺癌肉瘤1例报道及文献复习.pdfVIP

维普资讯 临床与实验病理学杂志 ．，ClinExpPathol2005Aug；20(4) ‘469 · 乳腺癌 肉瘤 1例报道及文献复习 戴 敏 ，杨文涛 [摘要] 目的 探讨乳腺癌肉瘤的临床病理学特征及其鉴别诊断。方法 对 1例乳腺癌肉瘤进行组织病理学和免疫表型观 察并复习文献 ，了解该肿瘤的特征。结果 镜检显示病变边界清楚，以软骨肉瘤为主，其边缘有少量分化较差的浸润性导管 癌成分。免疫表型：软骨肉瘤细胞 vimentin强阳性，S-100蛋 白阳性 ，ER、PR、c—erbB一2和 CK(AEI／AE3)均阴性；癌细胞 CK (AEI／AE3)、ER、PR及 c—erbB一2均阳性 ，vimentin、S-100蛋白阴性。结论 原发于乳腺的癌肉瘤较罕见，诊断需与乳腺恶性分 叶状肿瘤 以及软组织肉瘤鉴别。 [关键词] 乳腺肿瘤；癌肉瘤；诊断，鉴别 [中图分类号] R737．9 [文献标识码] A [文章编号] 1001—7399(2005)o4一o469一o3 Carcinosarcomaofthebreast：acasereportandreview oftheliterature DAIMin ．YANG Wen．tao (DepartmentofPathology， “SecondPeople’sHospitalofAnhuiProvince， “ 241000，China； DepartmentofPathology，CancerHospital，FudanUniversity，Shanghai200032，China) [Abstract] Purpose Toinvestigatetheclinicalandpathologicalfeaturesofbreastcarcinosarcomaanditsdifferentialdiagnosis． M ethods Thehistopathologyandimmunophenotypeofabreastcarcinosarcomawasstudiedandtherelativeliteraturewerereviewedin ordertounderstandthecharacteristicsofthetumor．Results Microscopically thelesionwasrelativelywellcircumscribed．Theturnor ． Was predominantlycomposedofchondrosarcomawithinvasiveductal carcinomaattheperipheryofthetumor．Thechondrosarcomaele— mentsshowedvimentin(+)，S-100protein(+)，ER(一)，PR(一)，c—erbB-2(一)，andCK(AEI／AE3)(一)．Th ecarcinomacells showedCK (AEI／AE3)(+)，ER(+)，PR(+)，c—erbB2(+)，vimentin(一)，andS-100protein(一)．Conclusions Primary carcinosarcomaofthebreastisarraetumor．Moreattentionshouldbepaidinthedailypracticeinordertodifferentiatethistumorfrom malignnatphyllodestumorandprimarysofttissuesracomaofthebreast ． [Keywords] breastneoplasms；carcinosarcoma；diagnosis，differential 乳腺的癌 肉瘤非常少见，WHO乳腺肿瘤新分