dd肿瘤干细胞和卵巢癌研究进展.pdfVIP

际生殖健康/ 计划生育杂志 20 10 年 3 月第29 卷第 2 期 J Int Reprod Health Fam Plan ，March 20 10熏 Vol. 29 熏 No. 2 123 综述 瘤干细胞与卵巢癌研究进展 丽娜综述 赵卫东审校 【摘 要】 近年肿瘤干细胞理论及其相关研究引起关注。该理论认为，肿瘤干细胞是恶性肿瘤发 生、耐药、复发及转移的根源，并最终导致恶性肿瘤靶向治疗失败，难以根治。卵巢癌治疗的最大障碍是肿 瘤细胞耐药性的产生，肿瘤干细胞的研究对解决卵巢癌等恶性肿瘤的高耐药、复发难题有重要意义。目 前，卵巢癌干细胞已经成功分离鉴定，但此方面的研究尚处于开始阶段。从肿瘤干细胞角 对卵巢癌干细 胞的性质及分离鉴定方法综述。 【关键词】 肿瘤干细胞；卵巢癌；SP 细胞；流式细胞仪 Advances of Cancer Stem Cells and Ovarian Cancer ZHA NG Li鄄na，ZHA O W ei鄄dong. De partment of Obs terics and Gynecology of A nhui Prov inc ial Hospital ，A nhui Medical Univ ers ity ，Hefe i 230001 ，China 【Abstract 】 In recent years ，cancer stem cells theory and study attracted peoples attention. The theory that the cancer stem cells are the root causes of malignant tumors occurrence ，resistance ，recurrence and metastasis ，and lead to targeted cancer treatment failure eventually being difficult to cure. The biggest obstacle to the treatment of ovarian cancer is the the emergence of drug resistance of tumor cells. It has the great significance for cancer stem cell research to solve the high鄄malignant tumors such as ovarian cancer drug resistance and relapse problems. At present ，ovarian cancer stem cells have been successfully isolated and identificated ，however, the research on the ovarian cancer stem cells is still in the primary stage. This paper provides an overview of the characteristics and isolation and identification methods of ovarian cancer stem cells from the perspective of cancer stem cells. 【Key words 】 Cancer stem cells ；Ovarian cancer ；SP ；Flow cytometry 渊 陨灶贼 砸藻责 则燥凿 匀藻葬造贼澡蛐云葬皂 孕造葬灶 袁2010 ，29 ：123-126 冤 [1] 卵巢癌（ovarian cancer ）是女性生殖器官常见的 生长、浸润、转移和复发中起关键性作 。随着研 肿瘤之一，发病率仅次于子宫