硝苯地平控释片对老年高血压患者肾功能的影响.pdfVIP

维普资讯 高血压杂志 ChineseJournalofHypertension 2002 Oct 10(5 ·443 · 文章编号 ：1006—2866(2002)05—0443—03 硝苯地平控释片对老年高血压患者 肾功能的影响 叶 蔚 ，马淑平 ，韩俊平 ，薛红元，高凤歧 (河北省人民医院，河北 石家庄 050051) EffectOfNifedipineModerateliberantonrenalfunction inagedpatients withhypertension YE Wei，MA Shu-ping，HAN Jun-ping，XUE Hong-yuan，GAO Feng-qi (HebeiProvic’ialPeople’SHospital，Shijiazhuang050051，China) Abstract Objective Ioinvestigatetheeffectofslowrelease(Adalat)ontherenalfunctionofagedpatientswithhyperten— sion． Methods Renalfunctionswereexaminde in 28 agde pa tientswith hypertensionbeforeandaftertreatmentwith Adaletusingradionucliderenographyandcolordopplerrenalhemodynamics． Theblc~xtandurinarybiochemicalanalysisin— D eludingblcxxlureanitrogen(BUN)，creatinine(Cr)，bloodp2一MG，urinep2一MGandurinealbuminweremeasurdeandocrre— latedwithglomerularfiltrationrate(GFR)． Thesystolicpeakvelocity(VS)，lowdiastolicflowvelocity(VD)，resistance D index(RI)andaccelerationtime(AT)inthearteriosustrunksegmentalarteryandinterlobararteryofkidneywereaclculat— ed． Results After12wksoftreatment(slow releasenifdeipine30rag～60mgqd)，SBPdcereasedby25％，DBPby C 17％．24hrmeanSBPandDBPby17％and15％ 0．001． VSandVDwereincreased(P0．01)，RIandATwerede— crased(P0．01)inarteriosustrunk，esgmentaryarterynadinterlobarrenalartery． GFRWas increased(P0．001)along withdcereasesinurinealbumin，urine 一MG andbloodcreatinine． Conclusion Slow releasenifde ipineSUbstantiallyin— cre~Lses renalblcxxtflowandGFRbydcereasingrenalve~,2ularresistanceandeffcetivelydcereasingsystme icBP． Theindices D representingrenalfunctionsuchasurinealbu