纳米银的生物学特性及其潜在毒性的研究进展.pdfVIP

842 环境与健康杂志2010 年9 月第27 卷第9 期 J Environ Health, September 2010, Vol．27, No．9 · · 【综述】 （ ） 文章编号：1001-5914 2010 09-0842-04 纳米银的生物学特性及其潜在毒性的研究进展 1,2,3 3 1,2 3 曲晨 ，刘伟 ，荣海钦 ，刘思金 摘要：纳米银是指粒径在纳米级（1~100 nm）的金属银单质。由于具有特殊的性能，纳米银在多个领域广泛应用。在医 学领域中，纳米银作为抗菌剂的主要成分大量应用于临床治疗。因此，纳米银的潜在毒性及其对健康的影响引起了人们的 广泛关注，研究表明纳米银存在不同程度的细胞毒性。该文综述了纳米银的医学生物学特性及其潜在毒性，认为透彻认识 纳米银的潜在毒性及其机理才能保证纳米银在临床治疗中的安全应用。 关键词：纳米银；生物学特性；细胞毒性 中图分类号：R994.6 文献标识码：A Research Advance on Biological Features and Toxicities of Silver Nanoparticles QU Chen, LIU Wei, RONG Hai-qin, et al. Shandong Institute of Endocrine and Metabolic Disease, Ji ’nan, Shandong 250062, China Corresponding author: LIU Si-jin ，E-mail: sjliu@rcees.ac.cn Abstract: Silver nanoparticles are nanoparticles of silver metal with size ranging from approximately 1 -100 nm in one dimension at least. Small size at the nano-scale confers special properties on silver nanoparticles, which have resulted in their widespread application in many fields. In the medical fields, silver nanoparticles are widely used as the main component for antibacterial reagents in clinical practice. However, the adverse effects or even toxicities from silver nanoparticles are concerned worldwide. And recent studies have confirmed the cytotoxicity of silver nanoparticles to normal cells. This paper presented the progress on the biological features and potential toxicities of silver nanoparticles. Key words: Silver nanoparticles; Biological characteristics; Cytotoxity 纳米材