冠心病患者对氧磷酶基因192位Gln_Arg多态性第研究.pdfVIP

2001; 32(3) :385388 JW CU M S 192 - Gln Arg * 1 2 3 2 1 1 2 刘　瑞 　白　怀　邓珏琳 　刘　宇 　黄明慧 　李　献 　刘秉文 1. ( 610041) ; 2. ; 3. ( ) ( ) 192 - CHD PON Gln Arg ( PCR) 118 128 PON ( RFLP) CHD PON QR , 0. 78 0. 2 0. 2 0. 0, CHD PON R ( 0. 0 ) ( 0.01) , P PON R P (P 0. 01) , PON 1 192 Gln-Arg CHD Gln-Arg 192 41.4 R The Paraoxonase Gln-Arg 192 Polymorphism in Patients with Coronary Heart Disease in Chinese PopulationLiu Rui* , Bai Huai, Deng J uelin, Liu Yu, Huang Minghui, Li Xian , Liu Bingwen. * L a borator y of I nter nal M ed icine , T he F ir st Af f iliated H osp ital , W C UM S , Chengdu 61004 1, China AbstractObj ecti eTo investigate the 192 Gln-Arg polymorphism of paraoxonase ( PON) gene and its relationship with serum lipids levels in pat ients with coronary heart disease in Chinese population. MethodsThe 192 - genotype and allele frequency of paraoxonase gene Gln Arg polymorphism was assayed by polymerase chain reaction ( PCR) -restriction fragment length polymorphism ( RFLP) . Serum lipids w ere measured by enzymatic kits in 118 CHD patients and 128 healthy subjects whose fasting serum T G levels were 1. 82 mmol/ L and T C levels 6. 2 / . mmol L from a population of Chinese Han nat ionality in Chengdu area Results Both in CHD group and , , 0. 78 0. 2 contr