脑脉泰胶囊对颈内动脉系统脑梗死脑循环动力学影响的临床研究.pdfVIP

《中国全科医学》2008年12月第12B期 脑脉泰胶囊对颈内动脉系统脑梗死脑循环动力学影 响的临床研究 张建斌 张丽玲 吴丽丽1 【摘 要】 目的 为观察和研究脑脉泰胶囊治疗颈内动脉系统动脉硬化性 脑梗死(ATCI)患者的疗效及对脑循环动力学的影响，对88例该病患者进行了脑 循环动力学观察。方法 采用随机、双盲和平行对照的方法，把患者分为两组， 同样接受脑梗死的基本治疗，而脑脉泰胶囊组病例，加用脑脉泰胶囊。对患者进 行用脑脉泰胶囊治疗前、治疗后的脑神经功能缺损评分，同时测定脑循环动力学 参数(CVDI)。结果 (1)脑脉泰胶囊组神经功能缺失，治疗有效率为91.3％，对照 组为78.6％。(2)脑脉泰胶囊组患者病灶一侧CVDI中，脑血流量(Q)及血流速度(V) 用脑脉泰胶囊治疗后较治疗前显著增加(P0．05)，较对照组亦有显著增加 (P0．05)。血管阻力(R)、弹性及临界压力(CP)经脑脉泰胶囊治疗后，较治疗前 明显降低(PO．05)，较病灶对侧大脑差异亦有显著性(PO．05)。结论 脑脉泰 胶囊治疗ATCI患者疗效好，能明显改善脑血流灌注，降低脑循环阻力，减少神 经功能缺损，从而达到治疗脑梗死的目的，作为脑梗死的治疗药物安全有效。 【关键词】脑脉泰胶囊；脑梗死；脑循环动力学参数；疗效；临床 Clinical research of naomaitai capsul on cerebral hemodynamics in patients with atherothrombotic cerebral infarction of the carotis interna arteria system. Zhang Jianbin,Zhang Liling,Wu Lili.Department of Neurology,Heji Hospital affiliated to Medical college of Changzhi, Changzhi 046000, China 【Abstract】Objective To observe and study the clinical efficacy of naomaitai capsul and its effect on cerebra hemodynamics in patients with atherothrombotic cerebral infarction(ATCI) of the carotis interna arteria system，we choose 88 patients in our hospital in research of cerebral hemodynamics. Methods This clinical trial was randomly double-blind and parallel controlled．The patients with ATCl were divided into two groups．All patients recieved same basic treatment；Thetreatmentgoup trented byoraladministrationofnaomaitaicapsul then scoring the condition of neural functional deficits before and after the treatment；at the same time the cerebrovascular dynamics index(CVDI) of the patients were measured．Results (1)The neural functional deficits of patients in trial group tended to be repaired．The effective rate (ER) was 91.3％，but the control group’s ER was 78.6％． (2)The total cerebral blood flow and velocity(V)in the focal side of brain after the treatment in the treatment group showed a statistically si