银杏叶片减轻大鼠肾小球硬化的实验研究.pdfVIP

·92 · Ch in J Pediatr, February 1998, V o l 36, N o. 2 · · 论著 银杏叶片减轻大鼠肾小球硬化的实验研究 刘铜林　徐钦儒　王韵琴　吴衡生　匡裕玖 　　【摘要】　目的　探讨防治肾小球硬化有效而可行的方法。方法　应用天然的血小板活化因子受 体拮抗剂银杏叶片, 预防性治疗实验性肾小球硬化大鼠。结果　银杏叶片可有效地保护实验性肾小 球硬化大鼠的肾小球和肾小管部分功能, 显著减轻肾脏病理损伤及肾小球硬化, 但对缓解肾病综合征 状态无明显效果。结论　血小板活化因子受体拮抗剂可有效减轻肾小球硬化的发生和发展。 【关键词】　植物提取物　　肾小球硬化症, 病灶性　　血小板活化因子 　 , An exper im en tal study on effects of Ginkgo biloba extract on glom erulosclerosis L iu T ong lin X u Q inru , W ang Y unqin, et al. D ep artm ent of P ed iatrics , T ongj i H osp ital , T ongj iM ed ical U niversity , W uhan 430030 【 】　 　 Abstract Objective To find out an effective and feasible therapy fo r p rogressive glom eru- . 　 lo sclero sis M ethods Experim ental glom erulo sclero tic rats w ere treated p reventively w ith Ginkgo , ( ) . 　 biloba extract a natural p latelet activating facto r PA F recep to r antagonist Results T he glom erular and tubular functions w ere p ro tected effectively, the renal lesion and glom erulo sclero sis , ′ w ere also reduced obviously but the p ro teinuria and neph ro tic state w eren t imp roved by Ginkgo biloba extract therapy. Conclusion 　PA F recep to r antagonist could effectively reduce renal injury and glom erulo sclero sis, and PA F m igh t be one of the impo rtant m ediato rs of glom erulo sclero sis in . th is model 【 】　 　　 , 　　 Key words P l