雷贝拉唑口服治疗反流性食管炎近期疗效观察.pdfVIP

雷贝拉吐口服治疗反流性食管炎近期疗效观察 崔淑兰，梁 坚2，王婉梅2，祝 斌2(1.广东药学院医院门诊部，广州市 510224;2广东医学院附属医院，湛 江市 524001) 中圈分类号 R975.2 文献标识码 A 文章编号 1672-2124(2003)06-0358-03 摘 要 目的:观察雷贝拉咬治疗反流性食管炎的临床疗效和不良反应。方法:将 120例反流性食管炎患者随抓分为3组:雷贝 拉吮组50例，v服雷贝拉吐20rng,叫;奥是拉吐对照组40例，a服奥美拉哇20mg,bi山法英替丁叶照组30例，v服法英替丁20 mg,bido疗程均为6周。结果 雷贝拉吐治疗组明显降低反流性食管炎症状积分，症状完全缓解率94.0%，并可明显改善内镜下 食管炎分级、pH4总反流次教和pH4总时间(%)。疗效与奥笑拉唆相似但卜明显优于法莫替丁时照组(P0.01)，且不良反应 少。结论:口服雷贝拉吐治疗反流性食管炎近期疗效明显、安全可靠， 关健词 雷贝拉咬 法莫替丁:贾食管反流病:反流性含管炙 ObservationoftheEfficiencyintheNearFutureofRabeprazolebyMouthintheTreatmentofReflus Esophagitis(RE) CUIShulan(1.HospitalClinicofGuangdongPharmacyCollege,Guangzhou 510224) LIANGJianzWANGWanmei2，ZHUBin2(2.TheAffiliatedHospitalofGuangdongMedicalCollege,Zhan jiang 52400I) ABSTRACT OBJECTIVE:ToobserveclinicalefficiencyandadversereactionofrabepazoleinthetreatmentofRE. METHODS:120patientswithREwererandomlydividedinto3groups:50patientswereinmbeprazolegmup,20mgmbe- prazolewastakenorally,gd;40patientswereinomeprazolecontrolgmup,20mgomeprazolewastakenorally,bid;30patients wereinfamotidinecontrolgmup,20mgfamotidinewastakenorally,bid.Everycourseoftreatmentwas6weeks.RESULTS: rabeprazoletreatmentgroupobviouslydecreasedsymptomintegralofRE,completeremissionrateofthesymptomswas 94.0%,itcouldalsoobviouslyimprovegradingofesophagitisunderendoscope,pH4totalrefuxingtimesandpH4cu- mutativetime(%).Itsefficiencywassimilartothatofomeprazole,butwasmuchbetterthanthatoffamotidinecontrolgroup (P0.01),adversereactionwasless.CONCLUSION:Theefficiencyinthenearfutureofrabeprazole勿mouthinthetreat- mentofREisobvious,safeandreliable. KEYWORDS mbepmzole;famotidine;gmttnesophagealrefluxdisease;refuxesophagitis 但，rmaoC的D“,受体的快速解离理论(fas卜of-从theory) [ 3 : 侯 静，徐贵云，马 崔，等.饭氮平与利培酮对血清催 认为，药物对催乳素的影响与其对D,受体结合的松紧、解离 乳素水平的影响J「1.u床精神19学杂志,2001,11(1):1. 的快慢有关。抓氮平对DA受体的结合较松，解离较快，对催 [ 4 WangDY,DestavolaBL,HolbrookRD,“ Therelation- 乳素分泌的影响较小;而利培酮则相反.故能较显著升高催乳