麝香祛痛凝胶的抗炎镇痛作用研究_方昕.pdfVIP

第 27 卷 第 6期 V ol. 27 No. 6 2 0 0 9 年 6 月 CH INESE ARCH IVES OF TRAD IT OI NAL CH INESE M ED CI INE Jun. 2 0 0 9 1 1 2 1 方 昕 , 金宇恒, 丛国红, 闫永波 ( 11, 117000; 21, 117000) : 目的: 研究麝香祛痛凝胶外涂给药的抗 镇痛作用方法: 采用二甲苯致小鼠耳肿胀小鼠热板舔后 足反应小鼠扭体反应外涂给药, 观察麝香祛痛凝胶的抗 镇痛作用结果: 麝香祛痛凝胶能减轻二甲苯所致 小鼠耳肿胀明显减少小鼠热板舔后足反应和冰醋酸所致小鼠扭体次数提高大鼠对温热刺激的痛阈值结论: 麝香祛痛凝胶具有一定的抗 镇痛作用 : 麝香祛痛凝胶; 抗 作用; 镇痛作用 : R2851 6 : A : 1673- 77 17( 2009) 06- 1174- 02 Study on A nalgesic and A nt-i inflamm atory E ffects of Shex iangqutong G el 1 1 2 1 FAN-X in , J N Y u-heng , CONG G uo-hong , YAN Y ong-bo ( 11B enxi Cen tral H osp ita,l Benxi 117000, L iaon ing, Ch ina; 21Benx i Ch in eseM ed ical H osp ital, B enxi 117000, L iaon ing, C h ina) Abstrac:t O bj ectiv e: T o study the anti- inflamm a to ry and analgesic effects of Shex iangqutong G e.lM ethod s: the m ode ls of aur icular edem a in m ice induced by d mi ethy l benzene, body-wt isting reaction induced by acetic acid and ho t-plate test in m icew ere prepared to study the ant-i inflamm atory and ana lgesic effects. T hen Shex iangqutong G elw as g iv en to the ra ts orr m icew ith externa l inuncttum. R esults: Shex iangqutong G e l inhib ited the aur icu lar edema, S ign ificantly reduced in m ice lick ing foo t response after the ho t plate and in m icew rith ing number because of acetic acid and inc rease in the hot stmi u- la te the pa in thresho ld. Conclusion: Shex iangqutong G e l exh ibit obv ious an ti- in famm atory and ana lges ic effects. Key w ords