老年痴呆的发病机制与治疗的研究进展_肖增平.pdfVIP

肖增平等 　老年痴呆的发病机制及治疗的研究进展 　第 1期 ·95 · 6　Canton DA , L itchfield DW The shap e of th ings to com e: an em erging role 14　D iazN ido J , Serrano L , H ernandez MA , et a lPho sp horylation of m icro for p rotein k inase CK2 in the regu lation of cell morp hology and the cy tubu le p rotein s in rat b rain at different developm ental stages: comp arison to skeleton 〔J 〕Cell Signal, 2006; 18 ( 3) : 26775 w ith that found in neu ronal cu ltures 〔J 〕J N eu rochem , 1990; 54 ( 1) : 7　L itchfield DW Protein k inase CK2: structu re, regu lation and role in cellu 2 1122 lar decision s of life and death 〔J 〕B iochem J , 2003; 369 ( 1) : 115 15　B renneisen P, W laschek M , Schwamborn E, et a lA ctivation of p rotein 8　Ryu SW ,W oo JH , Kim YH , et a lDownregu lation of p rotein k inase CK II k inase CK2 is an early step in the u ltraviolet B m ediated increase in in is associated w ith cellu lar senescence 〔J 〕FEB S L ett, 2006; 580 ( 3 ) : terstitial collagenase (m atrix m etallop roteinase1;MM P1) and strom el 98894 ysin1 (MM P3) p rotein levels in hum an derm al fibrob lasts 〔J 〕 B io 9　J indal HK, A i Z, Gascard P, et a lSp ecific lo ss of p rotein k inase activities chem J , 2002; 365 ( 1) : 3 140 in senescent erythrocytes 〔J 〕B lood, 1996; 88 (4) : 147987 16　J in LW , Saitoh TChanges in p rotein k inases in b rain aging and A lzhei 10　Dumb le M , Gatza C, Tyner S, et a l In sights into aging ob tained from p53 m er ′s disease Imp lication s for drug therapy 〔J 〕D rugs A ging, 1995; 6 mu tant mou se models 〔J 〕Ann N Y A cad Sci, 2004; 1019 ( 6) : 17 17 (2) : 13649 11　V arela I, Cadinano s J , Pendas AM , et a lA ccelerated aging in m ice defi 17 　Bu rnett G, Kennedy EPThe enzym atic p ho sphorylation of p rotein s 〔J 〕 ci