传染主任cedil;-Bacillary Dysentery (shigellosis).ppt

Bacillary Dysentery (shigellosis) Dept. Of Infectious Disease Huang Fen Definition Acute infectious disease of intestine caused by dysentery bacilli Place of lesion: sigmoid rectum Pathological feature: diffuse fibrious exudative inflammation Definition Clinical manifestation: fever, abdominal pain, diarrhea, tenesmus , stool mixed with mucus blood, pus. even companied with shock and toxic encepholopthy. Etiology Causative organism: dysentery bacilli, genus shigellae, gram-stain negative, short rod, non-motile Groups: 4 serogroups 47 serotypes S. Dysenteriae the most severe Etiology S. Flexneri the epidemic group and easily turn to chronic S. Boydii tropical areas S. sonnei the most mild Etiology Pathogenicity: - virulence endotoxin - interotoxin (exotoxin) - invasiveness (attach-penetrate-multiply) Resistance: Strong, 1-2week in fruits,vegetable and dirty soil, heat for 60℃ 30 min Epidemiology Source of infection: patients and carriers Route of transmission: fecal-oral route Suceptibility of population: immunity after infection is short and unsteady, no cross-immune Epidemiology Epidemic features: season: summer fall Flexneri, Soneii, age: younger children Pathogenesis number of bacteria pathogenicity toxicity invasiveness attachment penetration multiplication immunity Pathology site of lesion: entire colon -sigmoid rectum feature: acute: diffuse fibrinous exudative inflammation, hyperemia, edema, leukocyte infiltration, necrosis, superficial ulceration. Pathology chronic: edema, ulceration, polypoid hyperplasia, toxic: hyperemia, edema, Clinical mani