严重脓毒症患儿血乳酸清除率和剩余碱变化及临床意义.pdfVIP

严重脓毒症患儿血乳酸清除率和剩余碱变化及临床意义 徐艳霞 陈建丽 肖德卫 唐熔 （贵阳市儿童院PICU，贵阳 550003 ） 【摘 要】 目的：探讨严重脓毒症患儿血乳酸清除率、剩余碱变化及其对预后的 早期评估作用。方法：回顾性分析78例严重脓毒症患儿入院时初始动脉血乳酸、 目标性治疗 6 小时的血乳酸清除率和剩余碱（BE） ，24 小时小儿危重症评分 （PCIS）及患儿预后的相关资料。将患儿分成存活组和死亡组，对上述指标进行 比较，同时将目标性治疗6小时的血乳酸清除率和BE 值与24小时PCIS值进行 相关性分析。结果：经目标性治疗6小时的生存组乳酸清除率、BE值和24小时 PCIS值均明显高于死亡组（P＜0.05）；,初始血乳酸浓度在两组无显著差异；目 标性治疗6小时的血乳酸清除率和BE 值与24小时PCIS值均具有明显相关性（P ＜0.05）。结论：乳酸清除率联合碱剩余、PCIS评分可综合评价严重脓毒症的病 情危重程度和预后。 【关键词】乳酸清除率；剩余碱；脓毒症；预后；儿童 Clinical significance of clearance rate of arterial blood lactic acid and base excess in children with severe sepsis Xu Yan-xia,et al. （PICU, Guiyang Children’s Hospital, Guiyang ） 【Abstract 】Objective：To investigate change of arterial blood lactic acid clearance rate, base excess(BE) in children with severe sepsis and the role on assessing prognosis. Methods ： Retrospective analysis relative data of initial level of arterial blood lactic acid, clearance rate of arterial blood lactic acid after 6 hours treatment and BE, patient care information system(PCIS) and prognosis in 78 patients with severe sepsis, were divided into two groups, survival group and died group, and have correlation analysis in clearance rate of arterial blood lactic acid after 6 hours treatment, BE and value of PCIS. Results ： The values of clearance rate of arterial blood lactic acid after 6 hours treatment, BE and PCIS were higher in survival group than that in died group(P ＜0.05); There was no difference in initial level of arterial blood lactic acid between two groups; and there were obvious correlation between clearance rate of arterial blood lactic acid after 6 hours treatment and BE with PCIS(P ＜0.05). Conclusion： Clearance rate of arterial blood lactic acid comining with BE 作者简介：徐艳霞（1983-），女，