聚乳酸及其在微球制剂中应用-郑振秋,张伟.pdfVIP

第 1 7 卷 第 2 期 辽宁中医药大学学报 Vol. 17 No. 2 2015 年 2 月 JOURNAL OF LIAONING UNIVERSITY OF TCM Feb .，2015 DOI：10.13194/j.issn.1673-842x.2015.02.048 聚乳酸及其在微球制剂中应用 1，2 2 郑振秋 ，张伟 （1. 山东中医药大学，山东 济南 250355；2. 青岛海慈医疗集团，山东 青岛 266033 ） 摘  要：目的：介绍聚乳酸合成和降解的方法以及以聚乳酸及其共聚物为基材制备微球的方法。方法：通过查 阅文献，阐述聚乳酸合成降解方法，针对聚乳酸在实际应用中存在的缺陷，介绍聚乳酸的改性方法，并讨论聚乳酸微 球的多种制备方法。结果：以聚乳酸为载体制备的微球可以应用于缓、控释制剂的研究。结论：聚乳酸有良好的生 物降解性和生物相容性，其微球制剂具有良好的应用前景。 关键词：聚乳酸；合成；降解；改性；微球制备 ( ) 中图分类号：R284.2 文献标志码：A 文章编号：1673-842X 2015 02- 0130- 04 Polylactic Acid and Its Application in Microsphere Preparation 1，2 2 ZHENG Zhenqiu ，ZHANG Wei （1. Shandong University of Traditional Chinese Medicine，Jinan 250355，Shandong， China；2. Qingdao Haici Medical Corp，Qingdao 266033，Shandong，China） Abstract：Objective ：To introduce the method of degradation and synthesis of polylactide and the method of preparing microspheres with polylactide and its copolymers as base material. Methods ： By reference to relevant literature，the paper expatiated the method of degradation and synthesis of polylactide，aiming at the existing defects of polylactide in the actual application. The modification of polylactide was expounded and the method of preparing microspheres with polylactide and its copolymers as base material were also discussed. Results ：Microspheres prepared with polylactide as the carrier can be used in the research of sustained and controlle