晚发性维生素K缺乏症31例临床分析.pdfVIP

网络出版时间：2015-01-16 08:54 网络出版地址：/kcms/detail/11.5189.R0854.024.html 论著·临床论坛 CHINESECOMMUNITY DOCTORS 晚发性维生素K缺乏症31例临床分析 任维莉 112700辽宁省铁法煤业集团总医院儿科 doi:10.3969/j.issn.1007-614x.2015.2.30 摘 要 目的：探讨婴儿晚发性维生素K缺乏症的临床特点、治疗及预防。方法：2010-2014年收治婴儿晚发性维生 素K缺乏症患者31例，给予对症治疗及使用5～10mg维生素K静滴，1次/d，连续使用3～5d。分析治疗效果。结 果：治愈18例，好转5例，放弃治疗2例，转上级医院3例，死亡3例。8例颅内出血存活患儿进行6个月～4年随 访，其中有4例患儿出现神经系统后遗症，主要表现为智能低下、肢体功能障碍、脑性瘫痪、癫痫、脑积水。结论： 晚发性维生素K缺乏症易并发颅内出血，该症起病突然，发展快，病死率高，愈后差。预防性应用维生素K对预防本 病的发生有重要的作用。 关键词 晚发性；维生素K缺乏；颅内出血；治疗；预防 Clinicalanalysisof31casesoflatevitaminKdeficiency RenWeili DepartmentofPediatrics,TiefaCoalIndustryGroupGeneralHospital,LiaoningProvince112700 Abstract Objective:ToinvestigatetheclinicalfeaturesofinfantiledelayedVitKdeficiency,treatmentandprevention.Methods: 31babywithlateonsetVitKdeficiencywereselectedfrom2010to2014.Theyweregivensymptomatictreatment,andintravenous dropof5～10mgofvitaminK, 1timeperday,continuous3～5days.Thetherapeuticeffectwasanalyzed.Results:18caseswere cured;5caseswereimproved;2casesgaveuptreatment;3casesturnedthesuperiorhospital;3casesdied.8casesofintracranial hemorrhageinchildrenlivewerefollowed-upfor 6 monthsto 4 years,4 casesappearedneurologicalsequelae,mainlyshowing mentalretardation,limbdysfunction,cerebralpalsy,epilepsyandhydrocephalus.Conclusion:LateonsetVitKdeficiencyeasily complicatedwithintracranialhemorrhage,thediseaseonsetsuddenly,rapiddevelopment,highmortalityrate,andtheprognosisis bad.ThepreventiveapplicationofVitKplaysanimportantroleinthepreventionofthisdisease. Keywords Lateonset;VitaminKdeficiency;Intracranialhemorrhage;Treatment;Prevent