氟比洛芬在肝癌射频消融术麻醉中应用.docVIP

氟比洛芬在肝癌射频消融术麻醉中的应用 作者：黄婉,龙浴辉,李毅,赖仁纯 作者单位：( 华南肿瘤学国家重点实验室//中山大学肿瘤防治中心 1. 麻醉科； 2. 肝胆科， 广东 广州 510060 ) 【摘要】 【目的】 探讨肝癌射频术中应用氟比洛芬是否可以减少静脉麻醉导致的呼吸抑制的发生。【方法】选择射频治疗肝癌患者60例，随机分为K组和N组，每组各30例，其中K组术前15 min静脉注射氟比洛芬50 mg，N组术前15 min静脉注射生理盐水5 mL，两组均以异丙酚复合瑞芬太尼微量泵维持麻醉。使记录术前、手术开始时、手术开始后5 min及患者术后苏醒时的平均动脉压、心率、脉搏氧饱和度及呼吸频率，监测动脉血二氧化碳分压；记录患者苏醒时间；记录出现术中体动、呼吸暂停的例数。【结果】 瑞芬太尼用量K组［（0.22±0.03）mg］显著少于N组[（0.51±0.07）mg，P 0.01］。术中体动K组（2例）少于N组（7例），呼吸暂停N组（12例）显著大于K组（2例）。【结论】 氟比洛芬可以减少肝癌射频术中瑞芬太尼的用量，降低呼吸抑制等副作用的发生率。 【关键词】 全凭静脉麻醉； 射频消融； 瑞芬太尼； 氟比洛芬 Application of Flurbiprofen Axetil Injection in Total Intravenous Anesthesia for Radiofrequency Ablation HUANG Wan1, LONG Yu-hui1, LI Yi1, LAI Ren-chun1, WANG Xu-dong1, CHEN Min-shan2, XU Mei-xi1 (1.Department of Anesthesiology, 2.Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in Southern China//Cancer Center, SUN Yat-sen University, Guangzhou 510060, China) Abstract: 【Objective】 Percutaneous radiofrequency ablation (PRFA) is a new and effective mini-invasive surgery for small hepatocellular carcinoma. This study was to observe if flurbiprofen axetil injection used in PRFA can reduce the reaction of respiratory depression.【Methods】 Sixty patients scheduled for PRFA were divided randomly into two groups: Group K and Group N. Those in Group K received flurbiprofen axetil injection at the dose of 50 mg 15 min before PRFA, and the patients in group N were given normal saline (NS) 5 mL at the same time. The two groups were given continuously intravenous infusion of remifentanil combined with propofol by micro pump. The mean arterial pressure (MAP), heart rate (HR), pulse oxygen saturation (SPO2), respiratory rate (RR), and partial pressure of carbon dioxide in artery (PaCO2) and recovery time were recorded. The lower limb movement, apnea, and body movements were recorded during operation. 【Results】The total consumption of remifentanil in group K [(0.22±0.03) mg] was less th