血小板计数及血浆D-二聚体水平与肺癌相关性研究.doc

血小板计数及血浆D-二聚体水平与肺癌相关性研究 罗育豪1，洪超群2，杜毓3，翁雪芬1 （1.汕头大学医学院附属肿瘤医院检验科，广东 汕头 515041；2. 汕头大学医学院附属肿瘤医院肿瘤研究室，广东汕头 515041；3.汕头大学医学院附属肿瘤医院设备科，广东 汕头 515041） 通信作者：翁雪芬，E-mail139.com。 摘要：目的：探讨肺癌患者与血浆血小板计数及D-二聚体水平的相关性研究；方法：回顾性分析155例肺癌患者及120例正常健康体检人群的血小板计数及血浆D-二聚体水平；结果：肺癌患者相比正常健康人群，血小板计数（301.90±61.13×?109/L vs 245.30±30.28×109/L）及血浆D-二聚体水平（805.35±1108.30ng/ml vs 130.94±81.93ng/ml）增高，差异具有统计学意义（P0.05），而肺癌患者中，发生远处转移患者相比原位癌患者，血小板计数（354.32±93.21×109/L vs 271.20±46.49×109/L）及血浆D-二聚体水平（1351.62±1692.32ng/ml vs 552.82±537.31ng/ml）进一步增高，差异具有统计学意义（P0.05）。结论：肺癌患者血小板计数及血浆D-二聚体水平与肺癌转移、预后存在相关性。 The correlations of platelet count and D-dimer level with lung cancer Luo Yuhao, Hong Chaoqun, Du Yu, Weng Xuefen (1 Department of Clinical Laboratory, 2 Oncological Research Lab, 3 equipment department, Cancer Hospital of Shantou University Medical College, Shantou, 515041.) Corresponding author: Weng Xuefen, Email:139.com. 【ABSTRACT】 Objective: To study the correlations of platelet count and D-dimer level with lung cancer. Methods: Retrospective analysis of platelet count and plasma D- dimer level in 155 patients with lung cancer and 120 normal healthy controls. Results: The platelet count and plasma D-dimer level were significantly higher in lung cancer than in normal controls (301.90±61.13×?109/L vs 245.30±30.28×109/L, P0.05; 805.35±1108.30ng/ml vs 130.94±81.93ng/ml, P0.05). Moreover, the platelet count and plasma D-dimer level were further higher in patients with distant metastasis of lung cancer than in patients with carcinoma in situ (354.32±93.21×109/L vs 271.20±46.49×109/L, P0.05; 1351.62?692.32ng/ml vs 552.82?37.31ng/mlan, P0.05). Conclusion: ?The platelet count and plasma D-dimer level in patients with lung cancer was associated with?disease progression and prognosis. [Keywords] Lung cancer ; platelet count; D- dimer 恶性肿瘤和凝血功能障碍存在密切关系，研究表明20%机体血栓事件与肿瘤引起相关，机体凝血功能亢进，一方面可导致血栓事件的发生，引起肿瘤患者血栓并发症[1]，另一方面多种止血、凝血相关因子参与肿瘤的发生、发展及转移[2]，越来越多的证据表明，血浆中止血、凝血相关因子浓度增高，不仅导致肿瘤触发，而且参与到肿瘤