茶叶的神经保护作用的研究进展.pdfVIP

茶叶的神经保护作用研究进展 李大祥，鲜 殊，杨 卫，宛晓春 （安徽农业大学茶叶生物化学与生物技术省部共建国家重点实验室培育基地，合肥 230036 ） 摘要：茶叶是一种天然健康饮料。中医认为饮茶能提神益思，延年益寿。现代医学研究表明，茶叶具有抗氧化、 防癌抗癌、预防心脑血管系统疾病、抗衰老、保护神经等功效。在神经保护中，茶叶中的儿茶素、L-茶氨酸、咖 啡碱等可通过互作，多途径、多靶点发挥作用。这些途径包括：抗氧化清除自由基，调节神经递质如谷氨酸、γ- 氨基丁酸、腺苷、乙酰胆碱等及其相关受体，防止胞内Ca2+超载，调节蛋白激酶PKC等信号途径，调节炎症因子， 提升神经营养因子水平，防止细胞凋亡。此外，饮茶再结合运动，则更有利于神经健康。随着研究的深入，茶叶 中的EGCG 、茶氨酸将是继咖啡碱后有望开发成神经类药物的活性成分。 关键词：茶学；茶叶；活性成分；抗氧化；神经保护 Progress on the Neuroprotective Effects of Tea LI Daxiang, XIAN Shu, YANG Wei, WAN Xiaochun (State Key Laboratory Cultivation Base of Tea Biochemistry Biotechnology, Anhui Agricultural University, Hefei 230036, China) Abstract: Tea is a natural healthy beverage. In the records of traditional Chinese medicine, tea has been shown to enhance longevity and promote soothing and refreshing. Recent medicinal researches have been proven that teas have the capacity of anti-oxidation, anti-carcinogenesis, anti-age, neuroprotection, and preventing the onsets of cardiovascular and cerebrovascular diseases. In the neuroprotective effects of tea, catechins, L-theanine and caffeine work together to modulate the nervous system especially central nervous system in a multi-targets way through multiple pathways, which include the modulation of neurotransmitters as glutamic acid, γ-aminobutyric acid and acetylcholine etc., and their receptors, prevention of intracellular calcium overloads, regulation of protein kinase C signal transduction pathway, modulation of inflammatory factors, elevation of the neurotrophic factors’ level, and attenuation of neuron apoptosis. Combined with physical activities, tea drinking would endow more prospective benefits